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The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission
Mounting evidence suggests that acute and chronic stress, especially the stress-induced
release of glucocorticoids, induces changes in glutamate neurotransmission in the prefrontal …
release of glucocorticoids, induces changes in glutamate neurotransmission in the prefrontal …
GFAP in health and disease
Glial fibrillary acidic protein (GFAP) is the main intermediate filament protein in mature
astrocytes, but also an important component of the cytoskeleton in astrocytes during …
astrocytes, but also an important component of the cytoskeleton in astrocytes during …
Astrocyte pathology in major depressive disorder: insights from human postmortem brain tissue
G Rajkowska, CA Stockmeier - Current drug targets, 2013 - ingentaconnect.com
The present paper reviews astrocyte pathology in major depressive disorder (MDD) and
proposes that reductions in astrocytes and related markers are key features in the pathology …
proposes that reductions in astrocytes and related markers are key features in the pathology …
Astrogliosis: an integral player in the pathogenesis of Alzheimer's disease
Alzheimer's disease is the main cause of dementia in the elderly and begins with a subtle
decline in episodic memory followed by a more general decline in overall cognitive abilities …
decline in episodic memory followed by a more general decline in overall cognitive abilities …
Astrocyte activation and reactive gliosis
Astrocytes become activated (reactive) in response to many CNS pathologies, such as
stroke, trauma, growth of a tumor, or neurodegenerative disease. The process of astrocyte …
stroke, trauma, growth of a tumor, or neurodegenerative disease. The process of astrocyte …
Neurochemical regulation of the expression and function of glial fibrillary acidic protein in astrocytes
Glial fibrillary acidic protein (GFAP), a type III intermediate filament, is a marker of mature
astrocytes. The expression of GFAP gene is regulated by many transcription factors (TFs) …
astrocytes. The expression of GFAP gene is regulated by many transcription factors (TFs) …
An astroglial basis of major depressive disorder? An overview
Q Wang, W Jie, JH Liu, JM Yang, TM Gao - Glia, 2017 - Wiley Online Library
Depression is a chronic, recurring, and serious mood disorder that afflicts up to 20% of the
global population. The monoamine hypothesis has dominated our understanding of the …
global population. The monoamine hypothesis has dominated our understanding of the …
Reactive astrocytes and therapeutic potential in focal ischemic stroke
Astrocytes are specialized and the most abundant cell type in the central nervous system
(CNS). They play important roles in the physiology of the brain. Astrocytes are also critically …
(CNS). They play important roles in the physiology of the brain. Astrocytes are also critically …
White matter astrocytes in health and disease
Myelination by oligodendrocytes is a highly specialized process that relies on intimate
interactions between the axon and the oligodendrocytes. Astrocytes have an important part …
interactions between the axon and the oligodendrocytes. Astrocytes have an important part …
Gliogenesis and glial pathology in depression
Recent research has changed the perception of glia from being no more than silent
supportive cells of neurons to being dynamic partners participating in brain metabolism and …
supportive cells of neurons to being dynamic partners participating in brain metabolism and …