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The toxicology of heparin reversal with protamine: past, present and future
Introduction: Unfractionated heparin is a strongly anionic anticoagulant used extensively in
medicine to prevent blood clotting. In the case of an emergency bleeding in response to …
medicine to prevent blood clotting. In the case of an emergency bleeding in response to …
Coagulation considerations for infants and children undergoing cardiopulmonary bypass
MP Eaton, EM Iannoli - Pediatric Anesthesia, 2011 - Wiley Online Library
Cardiac surgery involving cardiopulmonary bypass imposes a significant pathophysiologic
burden on patients. Pediatric patients are especially predisposed to the adverse effects of …
burden on patients. Pediatric patients are especially predisposed to the adverse effects of …
A novel antidote-controlled anticoagulant reduces thrombin generation and inflammation and improves cardiac function in cardiopulmonary bypass surgery
Heparin and protamine are the standard anticoagulant–antidote regimen used in almost
every cardiopulmonary bypass (CPB) procedure even though both are associated with an …
every cardiopulmonary bypass (CPB) procedure even though both are associated with an …
Cardiopulmonary bypass in the pediatric population
Cardiopulmonary bypass (CPB) facilitates the repair of cardiac lesions in adults and
children. Surgical mortality has decreased with improvements in technique allowing for the …
children. Surgical mortality has decreased with improvements in technique allowing for the …
A randomized, partially blinded, multicenter, active-controlled, dose-ranging study assessing the safety, efficacy, and pharmacodynamics of the REG1 anticoagulation …
Anticoagulants are the cornerstone of current acute coronary syndrome (ACS) therapy;
however, anticoagulation regimens that aggressively reduce ischemic events are almost …
however, anticoagulation regimens that aggressively reduce ischemic events are almost …
Anticoagulation strategies in pediatric cardiopulmonary bypass, weight-based vs. concentration-based approaches
J Harnish, K Beyer, J Collins - The journal of extracorporeal …, 2022 - ject.edpsciences.org
Pediatric patients undergoing cardiopulmonary bypass (CPB) require adequate
anticoagulation to combat hemostatic activation. Heparin is used to bind and catalyze …
anticoagulation to combat hemostatic activation. Heparin is used to bind and catalyze …
Cardiopulmonary bypass and the coagulation system
T Yeh Jr, MN Kavarana - Progress in Pediatric cardiology, 2005 - Elsevier
Cardiopulmonary bypass exerts intended and unintended effects on the enzymatic and
formed elements of the coagulation and inflammatory systems. Compared with adults …
formed elements of the coagulation and inflammatory systems. Compared with adults …
A pilot study indicating that bradykinin B2 receptor antagonism attenuates protamine‐related hypotension after cardiopulmonary bypass
M Pretorius, FG Scholl, JA McFarlane… - Clinical …, 2005 - Wiley Online Library
Background The administration of protamine to patients who received heparin during
cardiopulmonary bypass (CPB) induces hypotension. Protamine inhibits the …
cardiopulmonary bypass (CPB) induces hypotension. Protamine inhibits the …
The Hemodynamic Effects of Protamine in Pediatric Patients Undergoing Pulmonary Artery Reconstruction and Unifocalization Surgery: A Pilot StudyHemodynamic …
X Li, ZA Fang, MMA Lennig, A Klein, D Char… - Journal of cardiothoracic …, 2025 - Elsevier
Objectives To determine protamine administration increases pulmonary artery pressures
(PAPs) in patients undergoing unifocalization or pulmonary artery reconstruction surgeries …
(PAPs) in patients undergoing unifocalization or pulmonary artery reconstruction surgeries …
[Retracted] Nursing Observation of Improved Administration Route of Protamine Sulfate Neutralizing Heparin
J Hu, S Zeng, Z Wang, Q Chen, Y Shi… - Journal of Healthcare …, 2022 - Wiley Online Library
In this study, we have evaluated and examined various nursing effects of improved
administration of protamine sulfate neutralizing heparin after cardiopulmonary bypass. For …
administration of protamine sulfate neutralizing heparin after cardiopulmonary bypass. For …