Nicotinamide phosphoribosyltransferase (NAMPT) possesses a vital role in mammalian
cells due to its activity as a rate-limiting enzyme in the biosynthesis of nicotinamide adenine …

Highlights•NAMPT is overexpressed in cancers, associating with a poor prognosis and
tumor progression.•Extensive efforts have been made to improve efficacy and safety of early …

Lung endothelia in the arteries, capillaries, and veins are heterogeneous in structure and
function. Lung capillaries in particular represent a unique vascular niche, with a thin yet …

Since the identification of SARS-CoV2 at the end of 2019, the COVID-19 pandemic has
affected more than 410 million people worldwide and killed almost 6 million [1, 2]. The …

Nicotinamide phosphoribosyltransferase (NAMPT) plays a central role in mammalian cell
metabolism by contributing to nicotinamide adenine dinucleotide biosynthesis. However …

Systemic infections, especially in patients with chronic diseases, may result in sepsis: an
explosive, uncoordinated immune response that can lead to multisystem organ failure with a …

Historically considered a metabolically inert cellular layer separating the blood from the
underlying tissue, the endothelium is now recognized as a highly dynamic, metabolically …

Rationale: Idiopathic pulmonary fibrosis (IPF) is an irreversible, fatal interstitial lung disease
lacking specific therapeutics. Nicotinamide phosphoribosyltransferase (NAMPT), the rate …

ABSTRACT Introduction Acute Respiratory Distress Syndrome (ARDS) is a heterogeneous
form of lung injury with severe hypoxemia and bilateral infiltrates after an inciting event that …

Aberrant overexpression of nicotinamide phosphoribosyltransferase (NAMPT) has been
reported in a variety of tumor cells and is a poor prognosis factor for patient survival. It plays …