The blood–brain barrier (BBB) prevents the brain uptake of most pharmaceuticals. This
property arises from the epithelial-like tight junctions within the brain capillary endothelium …

The occurrence of altered brain glucose metabolism has long been suggested in both
diabetes and Alzheimer's diseases. However, the preceding mechanism to altered glucose …

J. Neurochem.(2011) 117, 333–345. Abstract We have obtained, for the first time, a
quantitative protein expression profile of membrane transporters and receptors in human …

Glutamate, released at a majority of excitatory synapses in the central nervous system,
depolarizes neurons by acting at specific receptors. Its action is terminated by removal from …

Mounting evidence from in vitro experiments indicates that lactate is an efficient energy
substrate for neurons and that it may significantly contribute to maintain synaptic …

To begin to study the importance of dopamine for executive function abilities dependent on
prefrontal cortex during early childhood, the present investigation studied children in whom …

The concept of a metabolic coupling between neurons and glia, particularly astrocytes,
geared at maintaining energy metabolism homeostasis in the brain has been entertained for …

Despite striking advances in functional brain imaging, the cellular and molecular
mechanisms that underlie the signals detected by these techniques are still largely …

Dichloroacetate (DCA) exerts multiple effects on pathways of intermediary metabolism. It
stimulates peripheral glucose utilization and inhibits gluconeogeneis, thereby reducing …

Tryptophan (Trp) availability for the kynurenine pathway (KP) across the life span is
discussed. Free (non-albumin-bound) plasma Trp is the major determinant of the flux of Trp …