Cisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is
limited by adverse effects in normal tissues. In particular, cisplatin is nephrotoxic and can …

Acute kidney injury (AKI) is a global public health concern associated with high morbidity
and mortality. Although advances in medical management have improved the in-hospital …

Renal tissue injury initiates inflammatory and fibrotic processes that occur to promote
regeneration and repair. After renal injury, damaged tissue releases cytokines and …

Chronic kidney disease (CKD) is an increasing global health burden. Current treatments for
CKD include therapeutics to target factors that contribute to CKD progression, including …

Burns are a seriously underestimated form of trauma that not only damage the skin system
but also cause various complications, such as acute kidney injury (AKI). Recent clinical …

Chronic kidney disease (CKD) has been recognized as an increasingly serious public
health problem globally over the decades. Accumulating evidence has shown that the …

Unilateral ischemia reperfusion injury (UIRI) with longer ischemia time is associated with an
increased risk of acute renal injury and chronic kidney disease. Exosomes can transport …

The effectiveness of cisplatin, a mainstay in the treatment of many solid organ cancers, is
hindered by dose-limiting nephrotoxicity. Cisplatin causes AKI in 30% of patients. Patients …

Renal interstitial fibrosis is a common pathological feature of chronic kidney disease that
may involve changes of metabolism in kidney cells. In the present study, we first showed that …

Acute kidney injury (AKI) remains a major global healthcare problem, and there is a need to
develop human-based models to study AKI in vitro. Toward this goal, we have characterized …