Comparing energy metabolism in human skeletal muscle and primary skeletal muscle cells
in obesity, while focusing on glucose and fatty acid metabolism, shows many common …

The beneficial health‐related effects of exercise are well recognized, and numerous studies
have investigated underlying mechanism using various in vivo and in vitro models. Although …

We hypothesized that skeletal muscle contraction produces a cellular stress signal,
triggering adipose tissue lipolysis to sustain fuel availability during exercise. The present …

In the context of type 2 diabetes, inter-individual variability in the therapeutic response of
blood glucose control to exercise exists to the extent that some individuals, occasionally …

New Findings What is the central question of this study? Is electrical pulse stimulation (EPS)
an in vitro exercise model able to elicit the hypertrophy of human muscle cells? What is the …

Type 2 diabetes (T2D) is characterized by muscle metabolic dysfunction that exercise can
minimize, but some patients do not respond to an exercise intervention. Myokine secretion is …

Exercise provides a cornerstone in the prevention and treatment of several chronic
diseases. The use of in vivo exercise models alone cannot fully establish the skeletal muscle …

Contraction of cultured myotubes with application of electric pulse stimulation (EPS) has
been utilized for investigating cellular responses associated with actual contractile activity …

Lifestyle disorders like obesity, type 2 diabetes (T2D), and cardiovascular diseases can be
prevented and treated by regular physical activity. During exercise, skeletal muscles release …

Aims Secreted protein acidic and rich in cysteine,(SPARC), is a matricellular protein
implicated in the modulation of the extracellular matrix (ECM) and mitochondrial proteins …