Targeted therapy in advanced non-small cell lung cancer: current advances and future trends

U Majeed, R Manochakian, Y Zhao, Y Lou - Journal of hematology & …, 2021 - Springer
Lung cancer remains the leading cause of cancer-related mortality in both men and women
in the US and worldwide. Non-small cell lung cancer is the most common variety accounting …

Molecular mechanism (s) of regulation (s) of c-MET/HGF signaling in head and neck cancer

S Raj, KK Kesari, A Kumar, B Rathi, A Sharma… - Molecular cancer, 2022 - Springer
Head and neck cancer is the sixth most common cancer across the globe. This is generally
associated with tobacco and alcohol consumption. Cancer in the pharynx majorly arises …

Drug resistance to targeted therapeutic strategies in non-small cell lung cancer

W Liu, Y Du, R Wen, M Yang, J Xu - Pharmacology & therapeutics, 2020 - Elsevier
Rapidly develo** molecular biology techniques have been employed to identify cancer
driver genes in specimens from patients with non-small cell lung cancer (NSCLC). Inhibitors …

[HTML][HTML] MET exon 14 skip** mutations in non–small-cell lung cancer: an overview of biology, clinical outcomes, and testing considerations

MA Socinski, NA Pennell, KD Davies - JCO precision oncology, 2021 - ncbi.nlm.nih.gov
In the United States, lung cancer is the second most frequently diagnosed type of cancer
and the leading cause of cancer deaths. 1 Non–small-cell lung cancer (NSCLC), which …

Biomarker-targeted therapies in non–small cell lung cancer: current status and perspectives

H Guo, J Zhang, C Qin, H Yan, T Liu, H Hu, S Tang… - Cells, 2022 - mdpi.com
Non-small-cell lung cancer (NSCLC) is one of the most common malignancies and the
leading causes of cancer-related death worldwide. Despite many therapeutic advances in …

Utility of incorporating next-generation sequencing (NGS) in an Asian non-small cell lung cancer (NSCLC) population: Incremental yield of actionable alterations and …

AC Tan, GGY Lai, G San Tan, SY Poon, B Doble… - Lung Cancer, 2020 - Elsevier
Objectives There is an expanding list of therapeutically relevant biomarkers for non-small
cell lung cancer (NSCLC), and molecular profiling at diagnosis is paramount. Tissue attrition …

Combinational blockade of MET and PD-L1 improves pancreatic cancer immunotherapeutic efficacy

E Li, X Huang, G Zhang, T Liang - Journal of Experimental & Clinical …, 2021 - Springer
Background Dysregulated expression and activation of receptor tyrosine kinases (RTKs) are
associated with a range of human cancers. However, current RTK-targeting strategies exert …

[HTML][HTML] Tyrosine kinase inhibitors

RJ Thomson, M Moshirfar, Y Ronquillo - StatPearls [Internet], 2023 - ncbi.nlm.nih.gov
Tyrosine Kinase Inhibitors - StatPearls - NCBI Bookshelf US flag An official website of the
United States government Here's how you know NIH NLM Logo Access keys NCBI Homepage …

MET-targeted therapies and clinical outcomes: a systematic literature review

Y Dong, J Xu, B Sun, J Wang, Z Wang - Molecular Diagnosis & Therapy, 2022 - Springer
Introduction Numerous therapeutic agents specifically targeting the mesenchymal-epithelial
transition (MET) oncogene are being developed. Objective The aim of the current review …

Therapeutic strategies in METex14 skip** mutated non-small cell lung cancer

LM Drusbosky, R Dawar, E Rodriguez… - Journal of Hematology & …, 2021 - Springer
METex14 skip** mutations occur in about 3–4% of lung adenocarcinoma patients and 1–
2% of patients with other lung cancer histology. The MET receptor tyrosine kinase and its …