Treating the Side Effects of Exogenous Glucocorticoids; Can We Separate the Good From the Bad?

R Pofi, G Caratti, DW Ray, JW Tomlinson - Endocrine Reviews, 2023 - academic.oup.com
It is estimated that 2% to 3% of the population are currently prescribed systemic or topical
glucocorticoid treatment. The potent anti-inflammatory action of glucocorticoids to deliver …

EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update

JS Smolen, R Landewé, J Bijlsma… - Annals of the …, 2017 - ard.bmj.com
Recent insights in rheumatoid arthritis (RA) necessitated updating the European League
Against Rheumatism (EULAR) RA management recommendations. A large international …

Long-term side effects of glucocorticoids

M Oray, K Abu Samra, N Ebrahimiadib… - Expert opinion on …, 2016 - Taylor & Francis
Introduction: Glucocorticoids represent the standard therapy for reducing inflammation and
immune activation in various diseases. However, as with any potent medication, they are not …

Low-dose interleukin-2 treatment selectively modulates CD4+ T cell subsets in patients with systemic lupus erythematosus

J He, X Zhang, Y Wei, X Sun, Y Chen, J Deng, Y **… - Nature medicine, 2016 - nature.com
Systemic lupus erythematosus (SLE) is a potentially life-threatening autoimmune disease
characterized by altered balance of activity between effector and regulatory CD4+ T cells …

EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update

JS Smolen, RBM Landewé, JWJ Bijlsma… - Annals of the …, 2020 - ard.bmj.com
Objectives To provide an update of the European League Against Rheumatism (EULAR)
rheumatoid arthritis (RA) management recommendations to account for the most recent …

[HTML][HTML] Current therapeutic options in the treatment of rheumatoid arthritis

BM Köhler, J Günther, D Kaudewitz… - Journal of clinical …, 2019 - mdpi.com
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic
inflammation of the joints. Untreated RA leads to a destruction of joints through the erosion …

2015 Recommendations for the management of polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative …

C Dejaco, YP Singh, P Perel, A Hutchings… - Annals of the …, 2015 - ard.bmj.com
Therapy for polymyalgia rheumatica (PMR) varies widely in clinical practice as international
recommendations for PMR treatment are not currently available. In this paper, we report the …

Defining conditions where long-term glucocorticoid treatment has an acceptably low level of harm to facilitate implementation of existing recommendations: viewpoints …

C Strehl, JWJ Bijlsma, M De Wit, M Boers… - Annals of the rheumatic …, 2016 - Elsevier
There is convincing evidence for the known and unambiguously accepted beneficial effects
of glucocorticoids at low dosages. However, the implementation of existing …

Inflammatory bone loss: pathogenesis and therapeutic intervention

K Redlich, JS Smolen - Nature reviews Drug discovery, 2012 - nature.com
Bone is a tissue undergoing continuous building and degradation. This remodelling is a
tightly regulated process that can be disturbed by many factors, particularly hormonal …

EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update

JS Smolen, R Landewé, FC Breedveld, M Buch… - Annals of the rheumatic …, 2014 - Elsevier
In this article, the 2010 European League against Rheumatism (EULAR) recommendations
for the management of rheumatoid arthritis (RA) with synthetic and biological disease …