Production of sperm and androgens is the main function of the testis. This depends on
normal development of both testicular somatic cells and germ cells. A genetic program …

In mammals, male gametes are produced inside the testis by spermatogenesis, which has
three phases: mitotic proliferation of spermatogonia, meiosis of spermatocytes, and haploid …

MicroRNAs (miRNAs) are active regulators of numerous biological and physiological
processes including most of the events of mammalian reproduction. Understanding the …

In recent years considerable effort has been devoted to understanding the epigenetic control
of sperm development, leading to an increased appreciation of the importance of RNA …

One of the most important develo** cell types in any biological system is the gamete
(sperm and egg). The transmission of phenotypes and optimally adapted physiology to …

The production of spermatozoa relies on a pool of spermatogonial stem cells (SSCs), formed
in infancy from the differentiation of their precursor cells, the gonocytes. Throughout adult …

Impaired biogenesis of microRNAs disrupts spermatogenesis and leads to infertility in male
mice. Spermatogonial differentiation is a key step in spermatogenesis, yet the mechanisms …

Spermatogenesis is characterized by meiotic divisions and major morphological changes to
produce spermatozoa that are capable of independent movement and fertilization of an egg …

Background RNA harbored by mammalian sperm is increasingly considered to be an
additional source of paternal hereditary information, beyond DNA. Recent studies have …

Recent progress in high throughput sequencing and bioinformatic analysis and other
biochemical methods have fuelled our appreciation for the important role of microRNAs …