Synucleinopathies are clinically and pathologically heterogeneous disorders characterized
by pathologic aggregates of α-synuclein in neurons and glia, in the form of Lewy bodies …

Neurodegenerative diseases are a common cause of morbidity and cognitive impairment in
older adults. Most clinicians who care for the elderly are not trained to diagnose these …

Although the pathogenesis of neurodegenerative diseases is still widely unclear, various
mechanisms have been proposed and several pieces of evidence are supportive for an …

Prions are proteins that adopt alternative conformations that become self-propagating; the
PrPSc prion causes the rare human disorder Creutzfeldt–Jakob disease (CJD). We report …

Multiple-system atrophy is a neurodegenerative disease characterized by progressive
autonomic failure, parkinsonism, and cerebellar and pyramidal tract symptoms. Glial …

Human genetics has indicated a causal role for the protein α-synuclein in the pathogenesis
of familial Parkinson's disease (PD), and the aggregation of synuclein in essentially all …

We describe the clinical, neuropathological, and genetic features of a Finnish patient with a
novel α-synuclein (SNCA) mutation A53E. The patient was clinically diagnosed with atypical …

Mitochondria are increasingly recognized as key players in genetic and acquired renal
diseases. Most mitochondrial cytopathies that cause renal symptoms are characterized by …

Identification of single-gene causes of steroid-resistant nephrotic syndrome (SRNS) has
furthered the understanding of the pathogenesis of this disease. Here, using a combination …

Parkinson disease (PD) and Parkinson-plus syndromes are genetically heterogeneous
neurological diseases. Initial studies into the genetic causes of PD relied on classical …