Berberine-containing plants have been traditionally used in different parts of the world for
the treatment of inflammatory disorders, skin diseases, wound healing, reducing fevers …

Metabolomics is the comprehensive assessment of endogenous metabolites and attempts to
systematically identify and quantify metabolites from a biological sample. Small-molecule …

Cardiovascular and metabolic diseases (CVMD) are the leading causes of death worldwide,
underscoring the urgent necessity to develop new pharmacotherapies. Berberine (BBR) is …

Ethnopharmacological relevance Berberine, extracted from Coptis Root and Phellodendron
Chinese, has been frequently used for the adjuvant treatment of type 2 diabetes mellitus …

Evidence shows that herbal medicine (HM) could be beneficial for the treatment of various
diseases. However, complexities present in HM due to the unclear bioactive compounds …

Background: Metabolic activity is the basic life activity of organisms and the fundamental for
maintaining body functions. With the improvement of living standards, the incidence of …

The prevalence of type 2 diabetes is associated with inflammatory bowels diseases,
nonalcoholic steatohepatitis and even a spectrum of cancer such as colon cancer and liver …

Background: Insulin secretory agents are commonly used to treat type 2 diabetes. However,
traditional insulin secretory agents such as sulfonylureas and glinides have side effects of …

Elevated levels of plasma free fatty acid (FFA) and disturbed mitochondrial dynamics play
crucial roles in the pathogenesis of diabetic kidney disease (DKD). However, the …

Traditional Chinese medicine (TCM) has attracted increasing interest throughout the world
because of its potential complementary therapy and an abundant source for new drug …