Determining the causes of schizophrenia has been a notoriously intractable problem,
resistant to a multitude of investigative approaches over centuries. In recent decades …

Alzheimer's disease (AD) is the leading cause of dementia in older adults. Although AD
progression is characterized by stereotyped accumulation of proteinopathies, the affected …

Cytosine DNA methylation is a highly conserved epigenetic mark in eukaryotes. Although
the role of DNA methylation at gene promoters and repetitive elements has been extensively …

Single-cell analyses parse the brain's billions of neurons into thousands of 'cell-type'clusters
residing in different brain structures. Many cell types mediate their functions through targeted …

The human hippocampus and prefrontal cortex play critical roles in learning and cognition,,
yet the dynamic molecular characteristics of their development remain enigmatic. Here we …

Recent advances in single-cell transcriptomics have illuminated the diverse neuronal and
glial cell types within the human brain. However, the regulatory programs governing cell …

Altered transcriptional and epigenetic regulation of brain cell types may contribute to
cognitive changes with advanced age. Using single-nucleus multi-omic DNA methylation …

The brain is composed of multiple regions associated with distinct functions, which have
become further specialized in the human lineage. To define how this specialization is …

Neuronal circuits represent the functional units of the brain. Understanding how the circuits
are generated to perform computations will help us understand how the brain functions …

Since the advent of Hi-C in 2009, a plethora of high-throughput sequencing methods have
emerged to profile the three-dimensional (3D) organization of eukaryotic genomes, igniting …