We discuss issues of structural and practical identifiability of partially observed differential
equations which are often applied in systems biology. The development of mathematical …

Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in the
western world. In the last three decades, fluid dynamics investigations have been an …

This systematic review of practical identifiability (PI) explores the challenging issue of how
parameter identification of models is affected by both experimental considerations and …

Healthcare is under increasing demand pressure as societies age and expectations rise,
multiplied by increasing incidence of chronic diseases and decreasing available funding …

Understanding the epidemiology of emerging pathogens, such as Usutu virus (USUV)
infections, requires systems investigation at each scale involved in the host–virus …

We aim to clarify our understanding of the process of state-space model input parameter
identification, known, within the clinical context, as model personalisation. To do so, we …

In-vivo studies of pulmonary vascular disease and pulmonary hypertension (PH) have
provided key insight into the progression of right ventricular (RV) dysfunction. Additional in …

Pulmonary hypertension (PH), defined as an elevated mean blood pressure in the main
pulmonary artery (MPA) at rest, is associated with vascular remodeling of both large and …

Mechanical ventilation is well known for having detrimental effects on the cardiovascular
system, particularly when using high positive end-expiratory pressure. High positive end …

Background and objective: Mechanical ventilation causes adverse effects on the
cardiovascular system. However, the exact nature of the effects on haemodynamic …