Photopharmacology is a novel technology in drug design that aims at solving poor drug
selectivity. This technology is currently in the proof-of-concept phase and relies on the …

Despite successfully utilizing anesthetics for over 150 years, the mechanism of action
remains relatively unknown. Recent studies have shown promising results, but due to the …

Photopharmacology uses molecular photoswitches to establish control over the action of
bioactive molecules. The application of photopharmacology in the research of invertebrate …

Medications for general anesthesia can cause smell alterations after surgery, with inhalation
anesthetics being the most acknowledged drugs. However, spine patients have been poorly …

Background The mechanisms underlying the role of T-type calcium channels (T-channels) in
thalamocortical excitability and oscillations in vivo during neurosteroid-induced hypnosis are …

Hypoxic conditions are rapidly sensed by the carotid body initiating the hypoxic ventilatory
response (HVR) pathways. TASK-1/3 K+ channels are responsible for this and a decrease in …

Anaesthetics are one of the most widely used pharmacological agents today, but the field of
anaesthesiology is quite young. A reversible state of amnesia, analgesia, immobility, and …

Transient receptor potential melastatin 8 channels (TRPM8s) are molecular sensors of
temperature. They are expressed in primary afferent neurons (PANs) and function as …

Recent progress has led to nucleotide-based gene silencing strategies as a potential
therapy for spinocerebellar ataxia type 3 (SCA3) and other hereditary ataxias. But recent …

In this review we will discuss ataxic disorders attributed to mutations in ion channel genes.
Such disorders seem to preferentially effect cerebellar Purkinje cell function, but not …