Two of the most prevalent human viruses worldwide, herpes simplex virus type 1 and type 2
(HSV-1 and HSV-2, respectively), cause a variety of diseases, including cold sores, genital …

Detection of evolutionarily conserved molecules on microbial pathogens by host immune
sensors represents the initial trigger of the immune response against infection. Cytosolic …

Many human cells can sense the presence of exogenous DNA during infection though the
cytosolic DNA receptor cyclic GMP-AMP synthase (cGAS), which produces the second …

Protein arginine methyltransferase 5 (PRMT5) controls diverse cellular processes and is
implicated in cancer development and progression. Here, we report an inverse correlation …

Innate immune activation by macrophages is an essential part of host defence against
infection. Cytosolic recognition of microbial DNA in macrophages leads to induction of …

The compendium of RNA-binding proteins (RBPs) has been greatly expanded by the
development of RNA-interactome capture (RIC). However, it remained unknown if the …

During acute HIV-1 infection, viral pathogen-associated molecular patterns are recognized
by pathogen-recognition receptors (PRRs) of infected cells, which triggers a signaling …

Interferon γ-inducible protein 16 (IFI16) and cGMP-AMP synthase (cGAS) have both been
proposed to detect herpesviral DNA directly in herpes simplex virus (HSV)-infected cells and …

Over the past decades the notion of 'inflammation'has been extended beyond the original
hallmarks of rubor (redness), calor (heat), tumor (swelling) and dolor (pain) described by …

The dysregulation of ROS production and osteoclastogenesis is involved in the progress of
osteoporosis. To identify novel and effective targets to treat this disease, it is important to …