Despite widespread clinical use of antimalarial drugs such as hydroxychloroquine and
chloroquine in the treatment of rheumatoid arthritis (RA), systemic lupus erythematosus …

B lymphocytes have a central role in autoimmune diseases, which are often defined by
specific autoantibody patterns and feature a loss of B cell tolerance. A prototypic disease …

Several studies have analyzed antiviral immune pathways in late-stage severe COVID-19.
However, the initial steps of SARS-CoV-2 antiviral immunity are poorly understood. Here we …

Rheumatoid arthritis (RA) is a debilitating autoimmune disease with grave physical,
emotional and socioeconomic consequences. Despite advances in targeted biologic and …

Systemic lupus erythematosus (SLE) is a severe chronic systemic autoimmune disease
caused by complicated interactions among genetic, epigenetic, and immunological factors …

IRAK-targeted therapies that have matriculated to early phase trials are yielding promising
preliminary results. However, studies of IRAK kinase signaling continue to defy conventional …

Systemic lupus erythematosus (SLE) is a genetically predisposed, female-predominant
disease, characterized by multiple organ damage, that in its most severe forms can be life …

Systemic lupus erythematosus (SLE) is an autoimmune illness marked by the loss of
immune tolerance and the production of autoantibodies against nucleic acids and other …

Growing pieces of evidence show that the long noncoding RNAs (lncRNAs) as new
regulators participate in the regulation of various physiological and pathological processes …

Natural killer (NK) cells are a specialised population of innate lymphoid cells (ILCs) that help
control local immune responses. Through natural cytotoxicity, production of cytokines and …