Global burden of thyroid cancer from 1990 to 2021: a systematic analysis from the Global Burden of Disease Study 2021

T Zhou, X Wang, J Zhang, E Zhou, C Xu, Y Shen… - Journal of Hematology & …, 2024 - Springer
Thyroid cancer (TC) is a significant global healthcare burden. However, the lack of
comprehensive data has impeded our understanding of its global impact. We aimed to …

Genomics Review of Selective RET Inhibitors Sensitivity in Thyroid Cancer Clinical Trials

S Gil‐Bernabé, L García‐DeLaFuente… - American Journal of …, 2025 - Wiley Online Library
ABSTRACT RET gene is a driver of thyroid cancer (TC) tumorigenesis. The incidence of TC
has increased worldwide in the last few decades, both in medullary and follicular‐derived …

Consensus Statement: Recommendations on Actionable Biomarker Testing for Thyroid Cancer Management

O Mete, A Boucher, KA Schrader, O Abdel-Rahman… - Endocrine …, 2024 - Springer
Thyroid cancer management is rapidly changing. The identification of actionable biomarkers
through both germline and somatic testing are now an integral part of directing patient …

PD-L1 and B7-H3 are effective prognostic factors and potential therapeutic targets for high-risk thyroid cancer

X Zhu, C Hu, Z Zhang, Y Zhu, W Liu, B Zheng… - Endocrine …, 2024 - Springer
The prognosis of thyroid cancer in patients varies significantly based on different
pathological types or distinct clinical situations. Investigating the expression of immune …

TERT upstream promoter methylation regulates TERT expression and acts as a therapeutic target in TERT promoter mutation-negative thyroid cancer

S Li, G Hu, Y Chen, Y Sang, Q Tang, R Liu - Cancer Cell International, 2024 - Springer
Background DNA hypermethylation and hotspot mutations were frequently observed in the
upstream and core promoter of telomerase reverse transcriptase (TERT), respectively, and …

Transcriptome of Anaplastic Thyroid Cancer Reveals Two Molecular Subtypes with Distinct Tumor Microenvironment and Prognosis

H Byun, HS Lee, YS Song, YJ Park - Thyroid, 2025 - liebertpub.com
Background: Although patients with anaplastic thyroid cancer (ATC) generally have a poor
prognosis and there are currently no effective treatment options, survival and response to …

High Prevalence of TBC1D12 5′UTR Mutations in Anaplastic Thyroid Cancer

G Hu, J Xue, J Yu, Q Dou, Y Sang, A Han, W Lv, J Li… - Thyroid, 2024 - liebertpub.com
Background: Anaplastic thyroid cancer (ATC) is a rare but one of the most lethal types of
human cancer. Although increasing evidence demonstrated that ATC tumors had a high …

Impacts of Immunotherapy on Patients With Aggressive Thyroid Carcinomas

AK Lam - JAMA oncology, 2024 - jamanetwork.com
Immunotherapy has represented a novel and cutting-edge approach to treating patients with
many types of metastatic cancers in recent years, transforming outcomes for patients who …

Exploring immune gene expression and potential regulatory mechanisms in anaplastic thyroid carcinoma using a combination of single-cell and bulk RNA sequencing …

K Zhou, S Zhang, J Shang, X Lan - Computational Biology and Chemistry, 2025 - Elsevier
Thyroid cancer includes papillary thyroid carcinoma (PTC) and anaplastic thyroid carcinoma
(ATC). While PTC has an excellent prognosis, ATC has a dismal prognosis, necessitating …

Columnar Cell Thyroid Carcinoma: A Heterogeneous Entity Demonstrating Overlap Between Papillary Thyroid Carcinoma and Follicular Neoplasms

KE Higgins, PM Sadow, DN Johnson, P Wang… - Head and Neck …, 2024 - Springer
Background Columnar cell papillary thyroid carcinoma (CC-PTC) is a morphologic subtype
of papillary thyroid carcinoma with a variable prognosis. It is characterized by neoplastic …