The cell-cell adhesion molecule E-cadherin
F Van Roy, G Berx - Cellular and molecular life sciences, 2008 - Springer
This review is dedicated to E-cadherin, a calcium-dependent cell-cell adhesion molecule
with pivotal roles in epithelial cell behavior, tissue formation, and suppression of cancer. As …
with pivotal roles in epithelial cell behavior, tissue formation, and suppression of cancer. As …
Involvement of members of the cadherin superfamily in cancer
G Berx, F Van Roy - Cold Spring Harbor perspectives in …, 2009 - cshperspectives.cshlp.org
We review the role of cadherins and cadherin-related proteins in human cancer. Cellular
and animal models for human cancer are also dealt with whenever appropriate. E-cadherin …
and animal models for human cancer are also dealt with whenever appropriate. E-cadherin …
E-cadherin germline mutations in familial gastric cancer
P Guilford, J Hopkins, J Harraway, M McLeod… - Nature, 1998 - nature.com
The identification of genes predisposing to familial cancer is an essential step towards
understanding the molecular events underlying tumorigenesis and is critical for the clinical …
understanding the molecular events underlying tumorigenesis and is critical for the clinical …
Central role of Snail1 in the regulation of EMT and resistance in cancer: a target for therapeutic intervention
S Kaufhold, B Bonavida - Journal of Experimental & Clinical Cancer …, 2014 - Springer
Snail1 is the founding member of the Snail superfamily of zinc-finger transcription factors,
which also includes Snail2 (Slug) and Snail3 (Smuc). The superfamily is involved in cell …
which also includes Snail2 (Slug) and Snail3 (Smuc). The superfamily is involved in cell …
E‐cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers.
Compelling experimental evidence exists for a potent invasion suppressor role of the cell‐
cell adhesion molecule E‐cadherin. In addition, a tumour suppressor effect has been …
cell adhesion molecule E‐cadherin. In addition, a tumour suppressor effect has been …
Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members
F Nollet, P Kools, F Van Roy - Journal of molecular biology, 2000 - Elsevier
Cadherins play an important role in specific cell-cell adhesion events. Their expression
appears to be tightly regulated during development and each tissue or cell type shows a …
appears to be tightly regulated during development and each tissue or cell type shows a …
Tumor suppressor gene E-cadherin and its role in normal and malignant cells
N Pećina-Šlaus - Cancer cell international, 2003 - Springer
E-cadherin tumor suppressor genes are particularly active area of research in development
and tumorigenesis. The calcium-dependent interactions among E-cadherin molecules are …
and tumorigenesis. The calcium-dependent interactions among E-cadherin molecules are …
Mutations of the human E‐cadherin (CDH1) gene
The cell–cell adhesion molecule E‐cadherin is well known to act as a strong invasion
suppressor in experimental tumor cell systems. Frequent inactivating mutations have been …
suppressor in experimental tumor cell systems. Frequent inactivating mutations have been …
Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin
KG Leong, K Niessen, I Kulic, A Raouf… - The Journal of …, 2007 - rupress.org
Aberrant expression of Jagged1 and Notch1 are associated with poor outcome in breast
cancer. However, the reason that Jagged1 and/or Notch overexpression portends a poor …
cancer. However, the reason that Jagged1 and/or Notch overexpression portends a poor …
Mesenchymal–epithelial transition (MET) as a mechanism for metastatic colonisation in breast cancer
As yet, there is no cure for metastatic breast cancer. Historically, considerable research effort
has been concentrated on understanding the processes of metastasis, how a primary …
has been concentrated on understanding the processes of metastasis, how a primary …