In eukaryotic cells, maintenance of genomic stability relies on the coordinated action of a
network of cellular processes, including DNA replication, DNA repair, cell-cycle progression …

Genome integrity is constantly monitored by sophisticated cellular networks, collectively
termed the DNA damage response (DDR). A common feature of DDR proteins is their …

Histones comprise the major protein component of chromatin, the scaffold in which the
eukaryotic genome is packaged, and are subject to many types of post-translational …

Cells respond to DNA double-strand breaks by recruiting factors such as the DNA-damage
mediator protein MDC1, the p53-binding protein 1 (53BP1), and the breast cancer …

The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …

Abstract p53-binding protein 1 (53BP1) is known to be an important mediator of the DNA
damage response, with dimethylation of histone H4 lysine 20 (H4K20me2) critical to the …

Life and death fate decisions allow cells to avoid massive apoptotic death in response to
genotoxic stress. Although the regulatory mechanisms and signalling pathways controlling …

In response to DNA damage eukaryotic cells activate cell cycle checkpoints—complex
kinase signaling networks that prevent further progression through the cell cycle. Parallel to …

Chromosomal double strand breaks provoke an extensive reaction in neighboring
chromatin, characterized by phosphorylation of histone H2AX on serine 139 of its C-terminal …

Coordinated progression through the cell cycle is a complex challenge for eukaryotic cells.
Following genotoxic stress, diverse molecular signals must be integrated to establish …