Pathway paradigms revealed from the genetics of inflammatory bowel disease

DB Graham, RJ Xavier - Nature, 2020 - nature.com
Inflammatory bowel disease (IBD) is a complex genetic disease that is instigated and
amplified by the confluence of multiple genetic and environmental variables that perturb the …

Microbial genes and pathways in inflammatory bowel disease

M Schirmer, A Garner, H Vlamakis… - Nature Reviews …, 2019 - nature.com
Perturbations in the intestinal microbiome are implicated in inflammatory bowel disease
(IBD). Studies of treatment-naive patients have identified microbial taxa associated with …

Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease

RS Mehta, JR Mayers, Y Zhang, A Bhosle… - Nature medicine, 2023 - nature.com
For decades, variability in clinical efficacy of the widely used inflammatory bowel disease
(IBD) drug 5-aminosalicylic acid (5-ASA) has been attributed, in part, to its acetylation and …

Commensal consortia decolonize Enterobacteriaceae via ecological control

M Furuichi, T Kawaguchi, MM Pust, K Yasuma-Mitobe… - Nature, 2024 - nature.com
Persistent colonization and outgrowth of potentially pathogenic organisms in the intestine
can result from long-term antibiotic use or inflammatory conditions, and may perpetuate …

AGA clinical practice guideline on the role of biomarkers for the management of ulcerative colitis

S Singh, AN Ananthakrishnan, NH Nguyen, BL Cohen… - Gastroenterology, 2023 - Elsevier
Background & Aims Biomarkers are used frequently for noninvasive monitoring and
treatment decision making in the management of patients with ulcerative colitis (UC). This …

Gut microbiota is a potential biomarker in inflammatory bowel disease

X Guo, C Huang, J Xu, H Xu, L Liu, H Zhao… - Frontiers in …, 2022 - frontiersin.org
Inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn's
disease (CD), is characterized by relapse and remission alternately. It remains a great …

[HTML][HTML] Inflammatory bowel disease treatments and predictive biomarkers of therapeutic response

DA Elhag, M Kumar, M Saadaoui, AK Akobeng… - International journal of …, 2022 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic immune-mediated inflammation of the
gastrointestinal tract with a highly heterogeneous presentation. It has a relapsing and …

[HTML][HTML] Metabolic functions of gut microbes associate with efficacy of tumor necrosis factor antagonists in patients with inflammatory bowel diseases

K Aden, A Rehman, S Waschina, WH Pan, A Walker… - Gastroenterology, 2019 - Elsevier
Background & Aims Altered interactions between the mucosal immune system and intestinal
microbiota contribute to pathogenesis of inflammatory bowel diseases (IBD). It is not clear …

Linking microbial genes to plasma and stool metabolites uncovers host-microbial interactions underlying ulcerative colitis disease course

M Schirmer, M Stražar, J Avila-Pacheco… - Cell Host & Microbe, 2024 - cell.com
Understanding the role of the microbiome in inflammatory diseases requires the
identification of microbial effector molecules. We established an approach to link disease …

Risk of colorectal cancer in inflammatory bowel diseases

MS Nadeem, V Kumar, FA Al-Abbasi, MA Kamal… - Seminars in cancer …, 2020 - Elsevier
Inflammatory bowel diseases (IBDs) are chronic problems of gastrointestinal tract (GIT) with
poorly understood aetiology. Patients with any of the two common entities, Crohn's disease …