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Pathway paradigms revealed from the genetics of inflammatory bowel disease
DB Graham, RJ Xavier - Nature, 2020 - nature.com
Inflammatory bowel disease (IBD) is a complex genetic disease that is instigated and
amplified by the confluence of multiple genetic and environmental variables that perturb the …
amplified by the confluence of multiple genetic and environmental variables that perturb the …
Microbial genes and pathways in inflammatory bowel disease
Perturbations in the intestinal microbiome are implicated in inflammatory bowel disease
(IBD). Studies of treatment-naive patients have identified microbial taxa associated with …
(IBD). Studies of treatment-naive patients have identified microbial taxa associated with …
Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease
For decades, variability in clinical efficacy of the widely used inflammatory bowel disease
(IBD) drug 5-aminosalicylic acid (5-ASA) has been attributed, in part, to its acetylation and …
(IBD) drug 5-aminosalicylic acid (5-ASA) has been attributed, in part, to its acetylation and …
Commensal consortia decolonize Enterobacteriaceae via ecological control
Persistent colonization and outgrowth of potentially pathogenic organisms in the intestine
can result from long-term antibiotic use or inflammatory conditions, and may perpetuate …
can result from long-term antibiotic use or inflammatory conditions, and may perpetuate …
AGA clinical practice guideline on the role of biomarkers for the management of ulcerative colitis
S Singh, AN Ananthakrishnan, NH Nguyen, BL Cohen… - Gastroenterology, 2023 - Elsevier
Background & Aims Biomarkers are used frequently for noninvasive monitoring and
treatment decision making in the management of patients with ulcerative colitis (UC). This …
treatment decision making in the management of patients with ulcerative colitis (UC). This …
Gut microbiota is a potential biomarker in inflammatory bowel disease
X Guo, C Huang, J Xu, H Xu, L Liu, H Zhao… - Frontiers in …, 2022 - frontiersin.org
Inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn's
disease (CD), is characterized by relapse and remission alternately. It remains a great …
disease (CD), is characterized by relapse and remission alternately. It remains a great …
[HTML][HTML] Inflammatory bowel disease treatments and predictive biomarkers of therapeutic response
Inflammatory bowel disease (IBD) is a chronic immune-mediated inflammation of the
gastrointestinal tract with a highly heterogeneous presentation. It has a relapsing and …
gastrointestinal tract with a highly heterogeneous presentation. It has a relapsing and …
[HTML][HTML] Metabolic functions of gut microbes associate with efficacy of tumor necrosis factor antagonists in patients with inflammatory bowel diseases
Background & Aims Altered interactions between the mucosal immune system and intestinal
microbiota contribute to pathogenesis of inflammatory bowel diseases (IBD). It is not clear …
microbiota contribute to pathogenesis of inflammatory bowel diseases (IBD). It is not clear …
Linking microbial genes to plasma and stool metabolites uncovers host-microbial interactions underlying ulcerative colitis disease course
Understanding the role of the microbiome in inflammatory diseases requires the
identification of microbial effector molecules. We established an approach to link disease …
identification of microbial effector molecules. We established an approach to link disease …
Risk of colorectal cancer in inflammatory bowel diseases
Inflammatory bowel diseases (IBDs) are chronic problems of gastrointestinal tract (GIT) with
poorly understood aetiology. Patients with any of the two common entities, Crohn's disease …
poorly understood aetiology. Patients with any of the two common entities, Crohn's disease …