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Pathological implication of protein post-translational modifications in cancer
S Pan, R Chen - Molecular aspects of medicine, 2022 - Elsevier
Protein post-translational modifications (PTMs) profoundly influence protein functions and
play crucial roles in essentially all cell biological processes. The diverse realm of PTMs and …
play crucial roles in essentially all cell biological processes. The diverse realm of PTMs and …
Transcription factors: Bridge between cell signaling and gene regulation
Transcription factors (TFs) are key regulators of intrinsic cellular processes, such as
differentiation and development, and of the cellular response to external perturbation …
differentiation and development, and of the cellular response to external perturbation …
20 years of the SMART protein domain annotation resource
Abstract SMART (Simple Modular Architecture Research Tool) is a web resource
(http://smart. embl. de) for the identification and annotation of protein domains and the …
(http://smart. embl. de) for the identification and annotation of protein domains and the …
Insights into the post-translational modification and its emerging role in sha** the tumor microenvironment
More and more in-depth studies have revealed that the occurrence and development of
tumors depend on gene mutation and tumor heterogeneity. The most important …
tumors depend on gene mutation and tumor heterogeneity. The most important …
[HTML][HTML] Decoding post-translational modification crosstalk with proteomics
Post-translational modification (PTM) of proteins allows cells to regulate protein functions,
transduce signals and respond to perturbations. PTMs expand protein functionality and …
transduce signals and respond to perturbations. PTMs expand protein functionality and …
In situ structural analysis of the human nuclear pore complex
Nuclear pore complexes are fundamental components of all eukaryotic cells that mediate
nucleocytoplasmic exchange. Determining their 110-megadalton structure imposes a …
nucleocytoplasmic exchange. Determining their 110-megadalton structure imposes a …
GPS-SUMO 2.0: an updated online service for the prediction of SUMOylation sites and SUMO-interacting motifs
Y Gou, D Liu, M Chen, Y Wei, X Huang… - Nucleic Acids …, 2024 - academic.oup.com
Small ubiquitin-like modifiers (SUMOs) are tiny but important protein regulators involved in
orchestrating a broad spectrum of biological processes, either by covalently modifying …
orchestrating a broad spectrum of biological processes, either by covalently modifying …
State of the interactomes: an evaluation of molecular networks for generating biological insights
Advancements in genomic and proteomic technologies have powered the creation of large
gene and protein networks (“interactomes”) for understanding biological systems. However …
gene and protein networks (“interactomes”) for understanding biological systems. However …
iPTMnet: an integrated resource for protein post-translational modification network discovery
Protein post-translational modifications (PTMs) play a pivotal role in numerous biological
processes by modulating regulation of protein function. We have developed iPTMnet (http …
processes by modulating regulation of protein function. We have developed iPTMnet (http …
The Plant PTM Viewer, a central resource for exploring plant protein modifications
P Willems, A Horne, T Van Parys… - The Plant …, 2019 - Wiley Online Library
Post‐translational modifications (PTM s) of proteins are central in any kind of cellular
signaling. Modern mass spectrometry technologies enable comprehensive identification and …
signaling. Modern mass spectrometry technologies enable comprehensive identification and …