Pathological implication of protein post-translational modifications in cancer

S Pan, R Chen - Molecular aspects of medicine, 2022 - Elsevier
Protein post-translational modifications (PTMs) profoundly influence protein functions and
play crucial roles in essentially all cell biological processes. The diverse realm of PTMs and …

Transcription factors: Bridge between cell signaling and gene regulation

P Weidemüller, M Kholmatov, E Petsalaki… - …, 2021 - Wiley Online Library
Transcription factors (TFs) are key regulators of intrinsic cellular processes, such as
differentiation and development, and of the cellular response to external perturbation …

20 years of the SMART protein domain annotation resource

I Letunic, P Bork - Nucleic acids research, 2018 - academic.oup.com
Abstract SMART (Simple Modular Architecture Research Tool) is a web resource
(http://smart. embl. de) for the identification and annotation of protein domains and the …

Insights into the post-translational modification and its emerging role in sha** the tumor microenvironment

W Li, F Li, X Zhang, HK Lin, C Xu - Signal transduction and targeted …, 2021 - nature.com
More and more in-depth studies have revealed that the occurrence and development of
tumors depend on gene mutation and tumor heterogeneity. The most important …

[HTML][HTML] Decoding post-translational modification crosstalk with proteomics

M Leutert, SW Entwisle, J Villén - Molecular & Cellular Proteomics, 2021 - Elsevier
Post-translational modification (PTM) of proteins allows cells to regulate protein functions,
transduce signals and respond to perturbations. PTMs expand protein functionality and …

In situ structural analysis of the human nuclear pore complex

A Von Appen, J Kosinski, L Sparks, A Ori, AL DiGuilio… - Nature, 2015 - nature.com
Nuclear pore complexes are fundamental components of all eukaryotic cells that mediate
nucleocytoplasmic exchange. Determining their 110-megadalton structure imposes a …

GPS-SUMO 2.0: an updated online service for the prediction of SUMOylation sites and SUMO-interacting motifs

Y Gou, D Liu, M Chen, Y Wei, X Huang… - Nucleic Acids …, 2024 - academic.oup.com
Small ubiquitin-like modifiers (SUMOs) are tiny but important protein regulators involved in
orchestrating a broad spectrum of biological processes, either by covalently modifying …

State of the interactomes: an evaluation of molecular networks for generating biological insights

SN Wright, S Colton, LV Schaffer, RT Pillich… - Molecular Systems …, 2025 - embopress.org
Advancements in genomic and proteomic technologies have powered the creation of large
gene and protein networks (“interactomes”) for understanding biological systems. However …

iPTMnet: an integrated resource for protein post-translational modification network discovery

H Huang, CN Arighi, KE Ross, J Ren, G Li… - Nucleic acids …, 2018 - academic.oup.com
Protein post-translational modifications (PTMs) play a pivotal role in numerous biological
processes by modulating regulation of protein function. We have developed iPTMnet (http …

The Plant PTM Viewer, a central resource for exploring plant protein modifications

P Willems, A Horne, T Van Parys… - The Plant …, 2019 - Wiley Online Library
Post‐translational modifications (PTM s) of proteins are central in any kind of cellular
signaling. Modern mass spectrometry technologies enable comprehensive identification and …