Lung cancers: molecular characterization, clonal heterogeneity and evolution, and cancer stem cells
Lung cancer causes the largest number of cancer-related deaths in the world. Most (85%) of
lung cancers are classified as non-small-cell lung cancer (NSCLC) and small-cell lung …
lung cancers are classified as non-small-cell lung cancer (NSCLC) and small-cell lung …
Moving pan-cancer studies from basic research toward the clinic
Although all cancers share common hallmarks, we have long realized that there is no silver-
bullet treatment for the disease. Many clinical oncologists specialize in a single cancer type …
bullet treatment for the disease. Many clinical oncologists specialize in a single cancer type …
Genomic and evolutionary classification of lung cancer in never smokers
Lung cancer in never smokers (LCINS) is a common cause of cancer mortality but its
genomic landscape is poorly characterized. Here high-coverage whole-genome sequencing …
genomic landscape is poorly characterized. Here high-coverage whole-genome sequencing …
Molecular characterization, biological function, tumor microenvironment association and clinical significance of m6A regulators in lung adenocarcinoma
Y Li, J Gu, F Xu, Q Zhu, Y Chen, D Ge… - Briefings in …, 2021 - academic.oup.com
Abstract N6-methyladenosine (m6A) modification can regulate a variety of biological
processes. However, the implications of m6A modification in lung adenocarcinoma (LUAD) …
processes. However, the implications of m6A modification in lung adenocarcinoma (LUAD) …
APOBEC3B and APOBEC mutational signature as potential predictive markers for immunotherapy response in non-small cell lung cancer
Non-small cell lung cancer (NSCLC) is known to carry heavy mutation load. Besides
smoking, cytidine deaminase APOBEC3B plays a key role in the mutation process of …
smoking, cytidine deaminase APOBEC3B plays a key role in the mutation process of …
GINS4 suppresses ferroptosis by antagonizing p53 acetylation with Snail
L Chen, Q Cai, R Yang, H Wang… - Proceedings of the …, 2023 - National Acad Sciences
Ferroptosis is an iron-dependent oxidative, nonapoptotic form of regulated cell death caused
by the destruction of redox homeostasis. Recent studies have uncovered complex cellular …
by the destruction of redox homeostasis. Recent studies have uncovered complex cellular …
[HTML][HTML] Analysis of immune-related signatures of lung adenocarcinoma identified two distinct subtypes: implications for immune checkpoint blockade therapy
Q Wang, M Li, M Yang, Y Yang, F Song… - Aging (albany …, 2020 - ncbi.nlm.nih.gov
Immune checkpoint blockade (ICB) therapies have revolutionized the treatment of human
cancers including lung adenocarcinoma (LUAD). However, our understanding of the …
cancers including lung adenocarcinoma (LUAD). However, our understanding of the …
The prognostic value of TP53 and its correlation with EGFR mutation in advanced non-small cell lung cancer, an analysis based on cBioPortal data base
XD Jiao, BD Qin, P You, J Cai, YS Zang - Lung Cancer, 2018 - Elsevier
Objectives The prognostic value of TP53 in advanced non-small-cell lung cancer (NSCLC)
is unclear. Whether different mutated exon has different prognostic value is unknown. We …
is unclear. Whether different mutated exon has different prognostic value is unknown. We …
Genetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma
Intratumor heterogeneity (ITH) of genomic alterations may impact prognosis of lung
adenocarcinoma (LUAD). Here, we investigate ITH of somatic copy number alterations …
adenocarcinoma (LUAD). Here, we investigate ITH of somatic copy number alterations …
The Role of TP53 Mutations in EGFR-Mutated Non-Small-Cell Lung Cancer: Clinical Significance and Implications for Therapy
Simple Summary Non-Small-Cell Lung Cancer (NSCLC) is the primary cause of cancer-
related death worldwide. Patients carrying Epidermal Growth Factor Receptor (EGFR) …
related death worldwide. Patients carrying Epidermal Growth Factor Receptor (EGFR) …