Metabolomics, which is the profiling of metabolites in biofluids, cells and tissues, is routinely
applied as a tool for biomarker discovery. Owing to innovative developments in informatics …

In the past decade, advances in liquid chromatography‐mass spectrometry (LC‐MS) have
revolutionized untargeted metabolomics analyses. By mining metabolomes more deeply …

Abstract Type 2 Diabetes Mellitus has reached epidemic proportions as a result of over-
nutrition and increasingly sedentary lifestyles. Current therapies, although effective, are not …

Diabetic retinopathy (DR) is one of the leading causes of visual impairment in the working-
age population. DR is a progressive eye disease caused by long-term accumulation of …

Diabetic retinopathy (DR) is a complication of diabetes and one of the leading causes of
vision loss worldwide. Despite extensive efforts to reduce visual impairment, the prevalence …

Metabolomics is the qualitative and quantitative assessment of the metabolites (small
molecules< 1.5 kDa) in body fluids. The metabolites are the downstream of the genetic …

Diabetic retinopathy (DR) is the main cause of vision loss or blindness in working age adults
worldwide. The lack of effective diagnostic biomarkers for DR leads to unsatisfactory curative …

Diabetic retinopathy (DR) is a universal microvascular complication of diabetes mellitus
(DM), which is the main reason for global sight damage/loss in middle-aged and/or older …

Diabetic retinopathy (DR), the leading cause of blindness in working-age adults, is one of
the most common complications of diabetes mellitus (DM) featured by metabolic disorders …

Arginase is a ubiquitous enzyme in the urea cycle (UC) that hydrolyzes L‐arginine to urea
and L‐ornithine. Two mammalian arginase isoforms, arginase1 (ARG1) and arginase2 …