ABSTRACT CYLD lysine 63 deubiquitinase (CYLD) is a ubiquitin hydrolase with important
roles in immunity and cancer. Complete CYLD ablation, truncation and expression of …

PTMs (posttranslational modifications) such as ubiquitylation, sumoylation, acetylation and
protein methylation are pivotal modifiers that determine the activation, deactivation or …

Gut-associated bacteria produce metabolites that both have a local influence on the
intestinal tract and act at a distance on remote organs. In Drosophila, bacteria-derived …

The Hippo signaling pathway plays an essential role in adult tissue homeostasis and organ
size control. Abnormal regulation of Hippo signaling can be a cause for multiple types of …

Cisplatin is one of the most effective chemotherapeutic agents commonly used for several
malignancies including oral squamous cell carcinoma (OSCC). Although cisplatin resistance …

Oral squamous cell carcinoma (OSCC) has a very poor prognosis because of its highly
invasive nature, and the 5‐year survival rate has not changed appreciably for the past 30 …

TNF is a potent cytokine known for its involvement in physiology and pathology. In
Rheumatoid Arthritis (RA), persistent TNF signals cause aberrant activation of synovial …

Microtubules are dynamic structures that are crucially involved in a variety of cellular
activities. The dynamic properties and functions of microtubules are regulated by various …

Epithelial morphogenesis and homeostasis are essential for animal development and tissue
regeneration, and epithelial disorganization is associated with developmental disorders and …

Oral health is an integral part of the general health and well-being of individuals. The
presence of oral disease is potentially indicative of a number of systemic diseases and may …