The potential and challenges of nanopore sequencing
A nanopore-based device provides single-molecule detection and analytical capabilities
that are achieved by electrophoretically driving molecules in solution through a nano-scale …
that are achieved by electrophoretically driving molecules in solution through a nano-scale …
Polymer translocation: the first two decades and the recent diversification
Probably no other field of statistical physics at the borderline of soft matter and biological
physics has caused such a flurry of papers as polymer translocation since the 1994 …
physics has caused such a flurry of papers as polymer translocation since the 1994 …
Polymer translocation and nanopore sequencing: a review of advances and challenges
Various biological processes involve the translocation of macromolecules across
nanopores; these pores are basically protein channels embedded in membranes …
nanopores; these pores are basically protein channels embedded in membranes …
Influence of polymer-pore interactions on translocation
We investigate the influence of polymer-pore interactions on the translocation dynamics
using Langevin dynamics simulations. An attractive interaction can greatly improve the …
using Langevin dynamics simulations. An attractive interaction can greatly improve the …
Sucking genes into pores: Insight into driven translocation
T Sakaue - Physical Review E—Statistical, Nonlinear, and Soft …, 2010 - APS
Flexible polymers such as long DNA, RNA molecules, and proteins, can pass through a
narrow pore whose size is comparable to their molecular thickness. We highlight the …
narrow pore whose size is comparable to their molecular thickness. We highlight the …
Unifying model of driven polymer translocation
We present a Brownian dynamics model of driven polymer translocation, in which
nonequilibrium memory effects arising from tension propagation (TP) along the cis side …
nonequilibrium memory effects arising from tension propagation (TP) along the cis side …
Sequence dependence of DNA translocation through a nanopore
We investigate the dynamics of DNA translocation through a nanopore using 2D Langevin
dynamics simulations, focusing on the dependence of the translocation dynamics on the …
dynamics simulations, focusing on the dependence of the translocation dynamics on the …
Modeling the separation of macromolecules: A review of current computer simulation methods
Abstract Theory and numerical simulations play a major role in the development of improved
and novel separation methods. In some cases, computer simulations predict counterintuitive …
and novel separation methods. In some cases, computer simulations predict counterintuitive …
Driven polymer translocation through nanopores: Slow-vs.-fast dynamics
We investigate the dynamics of polymer translocation through nanopores under external
driving by 3D Langevin Dynamics simulations, focusing on the scaling of the average …
driving by 3D Langevin Dynamics simulations, focusing on the scaling of the average …
Influence of non-universal effects on dynamical scaling in driven polymer translocation
We study the dynamics of driven polymer translocation using both molecular dynamics (MD)
simulations and a theoretical model based on the non-equilibrium tension propagation on …
simulations and a theoretical model based on the non-equilibrium tension propagation on …