Future of digital assays to resolve clinical heterogeneity of single extracellular vesicles

RTT Morales, J Ko - ACS nano, 2022‏ - ACS Publications
Extracellular vesicles (EVs) are complex lipid membrane vehicles with variable expressions
of molecular cargo, composed of diverse subpopulations that participate in the intercellular …

Extending the “one strain many compounds”(OSMAC) principle to marine microorganisms

S Romano, SA Jackson, S Patry, ADW Dobson - Marine drugs, 2018‏ - mdpi.com
Genomic data often highlights an inconsistency between the number of gene clusters
identified using bioinformatic approaches as potentially producing secondary metabolites …

Nanopore single-molecule analysis of biomarkers: Providing possible clues to disease diagnosis

X Chen, S Zhou, Y Wang, L Zheng, S Guan… - TrAC Trends in …, 2023‏ - Elsevier
Biomarker detection has attracted increasing interest in recent years due to the minimally or
non-invasive sampling process. Single entity analysis of biomarkers is expected to provide …

“Development and application of analytical detection techniques for droplet-based microfluidics”-A review

W Liu, Y Zhu - Analytica Chimica Acta, 2020‏ - Elsevier
Droplet-based microfluidics has emerged as a powerful platform for high-throughput and low-
volume analysis and screening. At present, droplet-based microfluidics is transitioning from …

Microfluidic technology for antibacterial resistance study and antibiotic susceptibility testing: review and perspective

N Qin, P Zhao, EA Ho, G **n, CL Ren - ACS sensors, 2020‏ - ACS Publications
A review on microfluidic technology for antibacterial resistance study and antibiotic
susceptibility testing (AST) is presented here. Antibiotic resistance has become a global …

[HTML][HTML] Microfluidic gas sensors: detection principle and applications

S Kaaliveetil, J Yang, S Alssaidy, Z Li, YH Cheng… - Micromachines, 2022‏ - mdpi.com
With the rapid growth of emerging point-of-use (POU)/point-of-care (POC) detection
technologies, miniaturized sensors for the real-time detection of gases and airborne …

Microfluidics-based sensing of biospecies

Y **ng, L Zhao, Z Cheng, C Lv, F Yu… - ACS Applied Bio …, 2020‏ - ACS Publications
Over the past decades, microfluidic devices based on many advanced techniques have
aroused widespread attention in the fields of chemical, biological, and analytical …

Nucleic acid analysis on electrowetting-based digital microfluidics

R Shen, S Yi, P Wang, PI Mak, RP Martins… - TrAC Trends in Analytical …, 2023‏ - Elsevier
Since the disclosure of DNA/RNA as the genetic material, nucleic acid analysis has been an
indispensable category in molecular diagnosis, disease prediction, prognosis, and …

A portable digital loop-mediated isothermal amplification platform based on microgel array and hand-held reader

L Cao, X Guo, P Mao, Y Ren, Z Li, M You, J Hu… - ACS …, 2021‏ - ACS Publications
Digital polymerase chain reaction (dPCR) has found widespread applications in molecular
diagnosis of various diseases owing to its sensitive single-molecule detection capability …

Single-molecule analysis of nucleic acid biomarkers–A review

T Gilboa, PM Garden, L Cohen - Analytica chimica acta, 2020‏ - Elsevier
Nucleic acids are important biomarkers for disease detection, monitoring, and treatment.
Advances in technologies for nucleic acid analysis have enabled discovery and clinical …