Recent advancements in gene editing illuminate new potential therapeutic approaches for
Sickle Cell Disease (SCD), a debilitating monogenic disorder caused by a point mutation in …

Genetic biocontrol aims to suppress or modify populations of species to protect public
health, agriculture, and biodiversity. Advancements in genome engineering technologies …

The synthesis of large RNA with precise modifications at specific positions is in high demand
for both basic research and therapeutic applications, but efficient methods are limited …

Synthetic CRISPR-Cas9 gene drive has been developed to control harmful species.
However, resistance to Cas9 gene drive can be acquired easily when DNA repair …

Aedes aegypti, known for transmitting viruses such as dengue, Zika and yellow fever, poses
a significant public health threat. Conventional insecticides give rise to a range of issues …

Due to limitations in conventional disease vector control strategies including the rise of
insecticide resistance in natural populations of mosquitoes, genetic control strategies using …

Background The recent success of a population control gene drive targeting the doublesex
gene in Anopheles gambiae paved the way for develo** self-sustaining and self-limiting …

Triatomine insects of the Hemiptera order are vectors of the neglected Chagas disease, that
inflicts a great health burden in the Americas. Vector control has been recognized as a …

The melanization process, which is essential for the proper functioning of the cuticle, has
been extensively investigated for its enzymatic roles and physiological effects …

CRISPR-Cas12a genome engineering systems have been widely used in plant research
and crop breeding. To date, the performance and use of anti-CRISPR-Cas12a systems have …