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Discovery of PIM-1 kinase inhibitors based on the 2, 5-disubstituted 1, 3, 4-oxadiazole scaffold against prostate cancer: Design, synthesis, in vitro and in vivo …
PIM-1 kinases play an established role in prostate cancer development and progression.
This research work tackles the design and synthesis of new PIM-1 kinase targeting 2, 5 …
This research work tackles the design and synthesis of new PIM-1 kinase targeting 2, 5 …
Design, synthesis, and biological evaluation of novel psoralen-based 1, 3, 4-oxadiazoles as potent fungicide candidates targeting pyruvate kinase
J Dong, W Gao, K Li, Z Hong, L Tang… - Journal of Agricultural …, 2022 - ACS Publications
Pyruvate kinase (PK) has been considered as a promising fungicide target discovered in our
previous studies. Natural compounds are important sources for discovery and development …
previous studies. Natural compounds are important sources for discovery and development …
Design, synthesis, and evaluation of antitumor activity in Pseudolaric acid B azole derivatives: Novel and potent angiogenesis inhibitor via regulation of the PI3K/AKT …
H Deng, Q Xu, XT Li, X Huang, JY Liu, R Yan… - European Journal of …, 2024 - Elsevier
Tumor proliferation and metastasis are intricately linked to blood vessel formation, with
vascular endothelial growth factor (VEGF) playing a pivotal role in orchestrating …
vascular endothelial growth factor (VEGF) playing a pivotal role in orchestrating …
Anti-cancer activity of capsaicin and its analogs in gynecological cancers
KC Brown, AM Sugrue, KB Conley… - … in cancer research, 2024 - pubmed.ncbi.nlm.nih.gov
Capsaicin is the hot and pungent ingredient of chili peppers. It is a potent pain-relieving
agent and is often present in over-the-counter analgesic lotions and creams. Several …
agent and is often present in over-the-counter analgesic lotions and creams. Several …
1, 2, 3-Triazole tethered hybrid capsaicinoids as antiproliferative agents active against lung cancer cells (A549)
A series of novel 1, 2, 3-triazole derivatives of capsaicin and its structural isomer (new
natural product hybrid capsaicinoid) were synthesized by exploiting one-/two-point …
natural product hybrid capsaicinoid) were synthesized by exploiting one-/two-point …
[HTML][HTML] Synthesis and Cytotoxic Activity of 1,2,4-Triazolo-Linked Bis-Indolyl Conjugates as Dual Inhibitors of Tankyrase and PI3K
A series of new 1, 2, 4-triazolo-linked bis-indolyl conjugates (15a–r) were prepared by
multistep synthesis and evaluated for their cytotoxic activity against various human cancer …
multistep synthesis and evaluated for their cytotoxic activity against various human cancer …
Capsaicin derivatives: Synthesis and biological activity
S Liu, X Zheng, J Wu, Y Zeng, X Wei… - Chemical Biology & …, 2024 - Wiley Online Library
Capsaicin is the main active ingredient of chili peppers and the most pungent alkaloid. It is
reported that capsaicin has many pharmacological effects such as analgesia, anticancer …
reported that capsaicin has many pharmacological effects such as analgesia, anticancer …
Interlinking Human-Derived Leukemia Cells with Clinicopathological Therapeutics: Exploring Capsaicin's Anti-Cancer Mechanisms/potential for Leukemia Patients …
Capsaicin, a bioactive compound isolated from chilli peppers, comes out as a potential
agent for its anti-proliferation role in leukemia patients' therapy. Objectives: This systematic …
agent for its anti-proliferation role in leukemia patients' therapy. Objectives: This systematic …