Amplified and distinctive genotoxicity of titanium dioxide nanoparticles in transformed yeast reporters with human cytochrome P450 (CYP) genes

T Jiang, L Hou, SM Rahman, Z Gong, X Bai… - Journal of Hazardous …, 2024 - Elsevier
Titanium dioxide nanoparticles (nTiO 2) have been considered a possible carcinogen to
humans, but most existing studies have overlooked the role of human enzymes in assessing …

CYP1B1 converts procarcinogens into genotoxins in Saccharomyces cerevisiae

A Kannan, N Perpetua, M Dolan, M Fasullo - Mutation Research/Genetic …, 2022 - Elsevier
CYP1B1 activates many chemical carcinogens into potent genotoxins, and allelic variants
are risk factors in lung, breast, and prostate cancer. However, few eukaryotic genetic …

High-Throughput Screening of the Saccharomyces cerevisiae Genome for 2-Amino-3-Methylimidazo [4,5-f] Quinoline Resistance Identifies Colon Cancer-Associated …

M Dolan, N St. John, F Zaidi, F Doyle, M Fasullo - bioRxiv, 2022 - biorxiv.org
Heterocyclic aromatic amines (HAAs) are potent carcinogenic agents found in charred
meats and cigarette smoke. However, few eukaryotic resistance genes have been identified …