Spatiotemporally Resolved Approach for Profiling Ferroptosis-Associated Metabolic Vulnerabilities in Tumors Using Mass Spectrometry Imaging and Stable Isotope …

H Geng, P Chen, Y Zhang, Z Zhu, Y Zhao… - Analytical …, 2024 - ACS Publications
Ferroptosis, as an iron-dependent cell death mediated by lipid peroxidation, has sparked
great interest in the tumor research community. Targeting ferroptosis has been proven to be …

An Untargeted Lipidomics Workflow Incorporating High-Resolution Demultiplexing (HRdm) Drift Tube Ion Mobility-Mass Spectrometry

DC Koomen, JC May, AJ Mansueto… - Journal of the …, 2024 - ACS Publications
Global discovery lipidomics can provide comprehensive chemical information toward
understanding the intricacies of metabolic lipid disorders such as dyslipidemia; however, the …

sn-Position-Resolved Quantification of Aminophospholipids by Isotopic N,N-Dimethyl Leucine Labeling and High-Resolution Ion Mobility Mass Spectrometry

S Xu, Z Zhu, TJ Gu, Z Wang, DG Delafield… - Analytical …, 2024 - ACS Publications
Aminophospholipids (APLs), composed of phosphatidylethanolamines (PEs) and
phosphatidylserines (PSs), are vital components of mammalian cell membranes and …