Influenza viruses are a major pathogen of both humans and animals. Recent studies using
gene-knockout mice have led to an in-depth understanding of the innate sensors that detect …

Tremendous progress has been made in understanding the molecular basis of the antiviral
actions of interferons (IFNs), as well as strategies evolved by viruses to antagonize the …

Influenza symptoms vary from mild disease to death; however, determinants of severity are
unclear. Type I interferons (IFNαβ) are recognized as key antiviral cytokines. Here we show …

This standard-setting textbook has defined the field of immunology since 1984, and is now in
its Seventh Edition continuing to deliver the detailed, authoritative, and timely coverage …

Influenza A virus (IAV)‐induced severe disease is characterized by infected lung epithelia,
robust inflammatory responses and acute lung injury. Since type I interferon (IFN αβ) and …

Fifty years after the discovery of the mouse Mx1 gene, researchers are still trying to
understand the molecular details of the antiviral mechanisms mediated by Mx proteins. Mx …

Influenza A virus (IAV) causes up to half a million deaths worldwide annually, 90% of which
occur in older adults. We show that IAV-infected monocytes from older humans have …

Ebola virus (EBOV) infection causes a severe and fatal hemorrhagic disease that in many
ways appears to be similar in humans and nonhuman primates; however, little is known …

Type I interferons (IFN-α/β) are potent antiviral cytokines and modulators of the adaptive
immune system. They are induced by viral infection or by double-stranded RNA (dsRNA), a …

While type I interferons (IFNs) are universally acknowledged for their antiviral and
immunostimulatory functions, there is increasing appreciation of the detrimental effects of …