Salivary gland function, development, and regeneration
Salivary glands produce and secrete saliva, which is essential for maintaining oral health
and overall health. Understanding both the unique structure and physiological function of …
and overall health. Understanding both the unique structure and physiological function of …
Prevention and treatment of radiotherapy‐induced side effects
L Barazzuol, RP Coppes, P van Luijk - Molecular oncology, 2020 - Wiley Online Library
Radiotherapy remains a mainstay of cancer treatment, being used in roughly 50% of
patients. The precision with which the radiation dose can be delivered is rapidly improving …
patients. The precision with which the radiation dose can be delivered is rapidly improving …
The evolving definition of salivary gland stem cells
C Rocchi, L Barazzuol, RP Coppes - NPJ Regenerative medicine, 2021 - nature.com
Dysfunction of the salivary gland and irreversible hyposalivation are the main side effects of
radiotherapy treatment for head and neck cancer leading to a drastic decrease of the quality …
radiotherapy treatment for head and neck cancer leading to a drastic decrease of the quality …
Autologous mesenchymal stem cells offer a new paradigm for salivary gland regeneration
M Marinkovic, ON Tran, H Wang… - International Journal of …, 2023 - nature.com
Salivary gland (SG) dysfunction, due to radiotherapy, disease, or aging, is a clinical
manifestation that has the potential to cause severe oral and/or systemic diseases and …
manifestation that has the potential to cause severe oral and/or systemic diseases and …
Hydrogels for the treatment of oral and maxillofacial diseases: Current research, challenges, and future directions
M Huang, Y Huang, H Liu, Z Tang, Y Chen… - Biomaterials …, 2022 - pubs.rsc.org
Oral and maxillofacial diseases such as infection and trauma often involve various organs
and tissues, resulting in structural defects, dysfunctions and/or adverse effects on facial …
and tissues, resulting in structural defects, dysfunctions and/or adverse effects on facial …
Mouth-watering results: Clinical need, current approaches, and future directions for salivary gland regeneration
C Rocchi, E Emmerson - Trends in molecular medicine, 2020 - cell.com
Permanent damage to the salivary glands and resulting hyposalivation and xerostomia have
a substantial impact on patient health, quality of life, and healthcare costs. Currently, patients …
a substantial impact on patient health, quality of life, and healthcare costs. Currently, patients …
Bioengineering in salivary gland regeneration
M Hajiabbas, C D'Agostino, J Simińska-Stanny… - Journal of biomedical …, 2022 - Springer
Salivary gland (SG) dysfunction impairs the life quality of many patients, such as patients
with radiation therapy for head and neck cancer and patients with Sjögren's syndrome …
with radiation therapy for head and neck cancer and patients with Sjögren's syndrome …
Development of a functional salivary gland tissue chip with potential for high-content drug screening
Radiation therapy for head and neck cancers causes salivary gland dysfunction leading to
permanent xerostomia. Limited progress in the discovery of new therapeutic strategies is …
permanent xerostomia. Limited progress in the discovery of new therapeutic strategies is …
Slow hydrogel matrix degradation enhances salivary gland mimetic phenotype
We recently developed a salivary gland tissue mimetic (SGm), comprised of salivary gland
cells encapsulated in matrix metalloproteinase (MMP)–degradable poly (ethylene glycol) …
cells encapsulated in matrix metalloproteinase (MMP)–degradable poly (ethylene glycol) …
A mesenchymal to epithelial switch in Fgf10 expression specifies an evolutionary-conserved population of ionocytes in salivary glands
Summary Fibroblast growth factor 10 (FGF10) is well established as a mesenchyme-derived
growth factor and a critical regulator of fetal organ development in mice and humans. Using …
growth factor and a critical regulator of fetal organ development in mice and humans. Using …