YAP/TAZ as master regulators in cancer: modulation, function and therapeutic approaches
S Piccolo, T Panciera, P Contessotto, M Cordenonsi - Nature cancer, 2023 - nature.com
Our understanding of the function of the transcriptional regulators YAP and TAZ (YAP/TAZ)
in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ …
in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ …
Insights into recent findings and clinical application of YAP and TAZ in cancer
Decades of research have mapped out the basic mechanics of the Hippo pathway. The
paralogues Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding …
paralogues Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding …
The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer
R Cunningham, CG Hansen - Clinical Science, 2022 - portlandpress.com
Tumorigenesis is a highly complex process, involving many interrelated and cross-acting
signalling pathways. One such pathway that has garnered much attention in the field of …
signalling pathways. One such pathway that has garnered much attention in the field of …
Signaling pathways involved in colorectal cancer: Pathogenesis and targeted therapy
Q Li, S Geng, H Luo, W Wang, YQ Mo, Q Luo… - … and Targeted Therapy, 2024 - nature.com
Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality
worldwide. Its complexity is influenced by various signal transduction networks that govern …
worldwide. Its complexity is influenced by various signal transduction networks that govern …
Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively …
W Ni, S Yao, Y Zhou, Y Liu, P Huang, A Zhou, J Liu… - Molecular cancer, 2019 - Springer
Background YAP activation is crucial for cancer development including colorectal cancer
(CRC). Nevertheless, it remains unclear whether N6-Methyladenosine (m 6 A) modified …
(CRC). Nevertheless, it remains unclear whether N6-Methyladenosine (m 6 A) modified …
Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine
The Hippo pathway and its downstream effectors, the transcriptional co-activators Yes-
associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) …
associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) …
Pharmacological blockade of TEAD–YAP reveals its therapeutic limitation in cancer cells
Targeting TEAD autopalmitoylation has been proposed as a therapeutic approach for YAP-
dependent cancers. Here we show that TEAD palmitoylation inhibitor MGH-CP1 and …
dependent cancers. Here we show that TEAD palmitoylation inhibitor MGH-CP1 and …
YAP/TAZ upstream signals and downstream responses
A Totaro, T Panciera, S Piccolo - Nature cell biology, 2018 - nature.com
Cell behaviour is strongly influenced by physical, mechanical contacts between cells and
their extracellular matrix. We review how the transcriptional regulators YAP and TAZ …
their extracellular matrix. We review how the transcriptional regulators YAP and TAZ …
[HTML][HTML] Treatment-induced tumor dormancy through YAP-mediated transcriptional reprogramming of the apoptotic pathway
Eradicating tumor dormancy that develops following epidermal growth factor receptor
(EGFR) tyrosine kinase inhibitor (TKI) treatment of EGFR-mutant non-small cell lung cancer …
(EGFR) tyrosine kinase inhibitor (TKI) treatment of EGFR-mutant non-small cell lung cancer …
Wnt signaling in cancer
Wnt signaling is one of the key cascades regulating development and stemness, and has
also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has …
also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has …