Impact of biologic therapy on the small airways asthma phenotype
The small airways dysfunction (SAD) asthma phenotype is characterised by narrowing of
airways< 2 mm in diameter between generations 8 and 23 of the bronchial tree. Recently …
airways< 2 mm in diameter between generations 8 and 23 of the bronchial tree. Recently …
Do small airway abnormalities characterize asthma phenotypes? In search of proof
The role of small airway abnormalities in asthma pathogenesis has been extensively studied
and debated for several decades. However, whether or not small airway abnormalities play …
and debated for several decades. However, whether or not small airway abnormalities play …
Mast cell–associated alveolar inflammation in patients with atopic uncontrolled asthma
BACKGROUND: A significant proportion of patients with asthma have persistent symptoms
despite treatment with inhaled glucocorticosteroids. OBJECTIVE: We hypothesized that in …
despite treatment with inhaled glucocorticosteroids. OBJECTIVE: We hypothesized that in …
Current treatment of severe asthma
S Hashimoto, EH Bel - Clinical & Experimental Allergy, 2012 - Wiley Online Library
Severe asthma is considered a heterogeneous disease in which a variety of clinical,
physiological and inflammatory markers determine disease severity. Pivotal studies in the …
physiological and inflammatory markers determine disease severity. Pivotal studies in the …
Physiological measurement of the small airways
S Verbanck - Respiration, 2012 - karger.com
Noninvasive physiological measurements are reviewed that have been reported in the
literature with the specific aim being to study the small airways in lung disease. This has …
literature with the specific aim being to study the small airways in lung disease. This has …
Severe refractory asthma: an update
RRL Wener, EH Bel - European Respiratory Review, 2013 - publications.ersnet.org
Asthma is a heterogeneous disease in which adequate asthma control cannot be achieved
in a substantial proportion despite currently available treatment possibilities. This subgroup …
in a substantial proportion despite currently available treatment possibilities. This subgroup …
Small airway disease in asthma: pathophysiological and diagnostic considerations
M Contoli, P Santus, A Papi - Current opinion in pulmonary …, 2015 - journals.lww.com
Clinicians, and not only researchers, must consider small airways when approaching
asthma patients, particularly when dealing with patients with a 'difficult-to-treat phenotype' …
asthma patients, particularly when dealing with patients with a 'difficult-to-treat phenotype' …
Ovalbumin-induced airway inflammation is ameliorated in Dectin-1–deficient mice, in which pulmonary regulatory T cells are expanded through modification of …
W Han, C Tang, S Baba, T Hamada… - The Journal of …, 2021 - journals.aai.org
Asthma is an allergic chronic respiratory disease that affects more than 300 million people
around the world. Dysbiosis of intestinal commensal microbiota influences the development …
around the world. Dysbiosis of intestinal commensal microbiota influences the development …
[HTML][HTML] Small airways dysfunction in severe asthma: Current treatment approaches and future directions
N Deng, Y **anyu, Y Xu, H Nie - Journal of the Formosan Medical …, 2025 - Elsevier
Severe asthma is a significant health concern due to its association with higher mortality
rates, reduced quality of life, and increased healthcare costs. These challenges make it a …
rates, reduced quality of life, and increased healthcare costs. These challenges make it a …
Postmortem serum levels of IgE and mast cell tryptase in fatal asthma
MP Scarpelli, S Keller, L Tran, C Palmiere - Forensic science international, 2016 - Elsevier
The aim of this study was to characterize the concentrations of total and specific IgE as well
as mast cell-derived tryptase in postmortem serum from femoral blood and evaluate the …
as mast cell-derived tryptase in postmortem serum from femoral blood and evaluate the …