Exosomal Bupivacaine: Integrating Nerve Barrier Penetration Capability and Sustained Drug Release for Enhanced Potency in Peripheral Nerve Block and Reduced …

Y Cai, Q Li, U Wesselmann… - Advanced Functional …, 2024 - Wiley Online Library
Peripherally injected local anesthetics exhibit limited ability to penetrate peripheral nerve
barriers, which limits their effectiveness in peripheral nerve block and increases the risk of …

Capsaicin-Loaded Melanin Nanoparticles for Long-Lasting Nociceptive-Selective Nerve Blockade

X Li, Q Li, X **a, E Deng, Y Zhao, Y He, C Zhao - Langmuir, 2024 - ACS Publications
Clinically used amino-ester and amino-amide local anesthetics, such as bupivacaine and
lidocaine, face two primary challenges: inadequate duration of action and nonselective …