Highlights•Involvement of corticostriatal circuits in OCD is receiving strong new experimental
support.•This evidence is concordant with clinical evidence based on OCD patient …

The domestic dog represents one of the most dramatic long-term evolutionary experiments
undertaken by humans. From a large wolf-like progenitor, unparalleled diversity in …

Behavioral genetics in dogs has focused on modern breeds, which are isolated subgroups
with distinctive physical and, purportedly, behavioral characteristics. We interrogated breed …

Discriminating the gene target of a distal regulatory element from other nearby transcribed
genes is a challenging problem with the potential to illuminate the causal underpinnings of …

Interactions between regulatory elements are of crucial importance for the understanding of
transcriptional regulation and the interpretation of disease mechanisms. Hi-C technique has …

Dogs are the most phenotypically diverse mammalian species, and they possess more
known heritable disorders than any other non-human mammal. Efforts to catalog and …

Chronic brain recordings suggest that seizure risk is not uniform, but rather varies
systematically relative to daily (circadian) and multiday (multidien) cycles. Here, one human …

Background Fear/anxiety and anger/aggression greatly influence health, quality of life and
social interactions. They are a huge burden to wellbeing, and personal and public …

Selective breeding of domestic dogs has generated diverse breeds often optimized for
performing specialized tasks. Despite the heritability of breed-typical behavioral traits …

Lymphoma is the most common hematological malignancy in developed countries. Outcome
is strongly determined by molecular subtype, reflecting a need for new and improved …