Based on publication and citation numbers liquid chromatography (LC–MS) has become the
major analytical technology in the field of global metabolite profiling. This dominance reflects …

Untargeted, global metabolite profiling (often described as metabonomics or metabolomics)
represents an expanding research topic and is, potentially, a major pillar for systems biology …

Proton nuclear magnetic resonance (NMR)-based metabolic phenoty** of urine and blood
plasma/serum samples provides important prognostic and diagnostic information and …

Metabolic profiling, metabolomic and metabonomic studies mainly involve the
multicomponent analysis of biological fluids, tissue and cell extracts using NMR …

Mass spectrometry (MS) techniques, because of their sensitivity and selectivity, have
become methods of choice to characterize the human metabolome and MS-based …

Metabolic challenge protocols, such as the oral glucose tolerance test, can uncover early
alterations in metabolism preceding chronic diseases. Nevertheless, most metabolomics …

The consequences of obstructive sleep apnea (OSA) are largely mediated by chronic
intermittent hypoxia and sleep fragmentation. The primary molecular domains affected are …

Systems biology has primarily focused on studying genomics, transcriptomics, and
proteomics and their dynamic interactions. These, however, represent only the potential for a …

Determining metabolomic differences among samples of different phenotypes is a critical
component of metabolomics research. With the rapid advances in analytical tools such as …

Metabonomics and metabolomics represent one of the three major platforms in systems
biology. To perform metabolomics it is necessary to generate comprehensive “global” …