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Circadian rhythm as a therapeutic target
The circadian clock evolved in diverse organisms to integrate external environmental
changes and internal physiology. The clock endows the host with temporal precision and …
changes and internal physiology. The clock endows the host with temporal precision and …
[HTML][HTML] A systematic review of the biological effects of cordycepin
M Radhi, S Ashraf, S Lawrence, AA Tranholm… - Molecules, 2021 - mdpi.com
We conducted a systematic review of the literature on the effects of cordycepin on cell
survival and proliferation, inflammation, signal transduction and animal models. A total of …
survival and proliferation, inflammation, signal transduction and animal models. A total of …
A signalling pathway for transcriptional regulation of sleep amount in mice
In mice and humans, sleep quantity is governed by genetic factors and exhibits age-
dependent variation,–. However, the core molecular pathways and effector mechanisms that …
dependent variation,–. However, the core molecular pathways and effector mechanisms that …
The transcriptional coactivator RUVBL2 regulates Pol II clustering with diverse transcription factors
Abstract RNA polymerase II (Pol II) apparatuses are compartmentalized into transcriptional
clusters. Whether protein factors control these clusters remains unknown. In this study, we …
clusters. Whether protein factors control these clusters remains unknown. In this study, we …
RUVBL1–RUVBL2 AAA-ATPase: a versatile scaffold for multiple complexes and functions
Highlights•RUVBL1–RUVBL2 forms a scaffold in macromolecular complexes such as R2TP
and chromatin remodelers.•RUVBL1–RUVBL2 ATPase activity is regulated by client …
and chromatin remodelers.•RUVBL1–RUVBL2 ATPase activity is regulated by client …
AAA ATPases as therapeutic targets: Structure, functions, and small-molecule inhibitors
Abstract ATPases Associated with Diverse Cellular Activity (AAA ATPase) are essential
enzymes found in all organisms. They are involved in various processes such as DNA …
enzymes found in all organisms. They are involved in various processes such as DNA …
Paraventricular hypothalamic RUVBL2 neurons suppress appetite by enhancing excitatory synaptic transmission in distinct neurocircuits
M **ng, Y Li, Y Zhang, J Zhou, D Ma, M Zhang… - Nature …, 2024 - nature.com
The paraventricular hypothalamus (PVH) is crucial for food intake control, yet the
presynaptic mechanisms underlying PVH neurons remain unclear. Here, we show that …
presynaptic mechanisms underlying PVH neurons remain unclear. Here, we show that …
Small-molecule modulators of the circadian clock: Pharmacological potentials in circadian-related diseases
Disruption of circadian oscillations has a wide-ranging impact on health, with the potential to
induce the development of clock-related diseases. Small-molecule modulators of the …
induce the development of clock-related diseases. Small-molecule modulators of the …
Nutritional compensation of the circadian clock is a conserved process influenced by gene expression regulation and mRNA stability
Compensation is a defining principle of a true circadian clock, where its approximately 24-
hour period length is relatively unchanged across environmental conditions. Known …
hour period length is relatively unchanged across environmental conditions. Known …
Circadian clock-controlled checkpoints in the pathogenesis of complex disease
The circadian clock coordinates physiology, metabolism, and behavior with the 24-h cycles
of environmental light. Fundamental mechanisms of how the circadian clock regulates organ …
of environmental light. Fundamental mechanisms of how the circadian clock regulates organ …