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Dysregulation of adult hippocampal neuroplasticity in major depression: pathogenesis and therapeutic implications
Major depressive disorder (MDD) was previously hypothesized to be a disease of
monoamine deficiency in which low levels of monoamines in the synaptic cleft were …
monoamine deficiency in which low levels of monoamines in the synaptic cleft were …
BDNF signaling in context: From synaptic regulation to psychiatric disorders
Brain-derived neurotrophic factor (BDNF) is a neuropeptide that plays numerous important
roles in synaptic development and plasticity. While its importance in fundamental physiology …
roles in synaptic development and plasticity. While its importance in fundamental physiology …
Assessing the mechanisms of brain plasticity by transcranial magnetic stimulation
Transcranial magnetic stimulation (TMS) is a non-invasive technique for focal brain
stimulation based on electromagnetic induction where a fluctuating magnetic field induces a …
stimulation based on electromagnetic induction where a fluctuating magnetic field induces a …
State-dependent effects of neural stimulation on brain function and cognition
Invasive and non-invasive brain stimulation methods are widely used in neuroscience to
establish causal relationships between distinct brain regions and the sensory, cognitive and …
establish causal relationships between distinct brain regions and the sensory, cognitive and …
Non-invasive transcranial ultrasound stimulation for neuromodulation
Transcranial ultrasound stimulation (TUS) holds great potential as a tool to alter neural
circuits non-invasively in both animals and humans. In contrast to established non-invasive …
circuits non-invasively in both animals and humans. In contrast to established non-invasive …
Synaptic plasticity forms and functions
Synaptic plasticity, the activity-dependent change in neuronal connection strength, has long
been considered an important component of learning and memory. Computational and …
been considered an important component of learning and memory. Computational and …
Bridging biological and artificial neural networks with emerging neuromorphic devices: fundamentals, progress, and challenges
As the research on artificial intelligence booms, there is broad interest in brain‐inspired
computing using novel neuromorphic devices. The potential of various emerging materials …
computing using novel neuromorphic devices. The potential of various emerging materials …
Synaptic plasticity and mental health: methods, challenges and opportunities
Activity-dependent synaptic plasticity is a ubiquitous property of the nervous system that
allows neurons to communicate and change their connections as a function of past …
allows neurons to communicate and change their connections as a function of past …
The role of inhibitory circuits in hippocampal memory processing
L Topolnik, S Tamboli - Nature Reviews Neuroscience, 2022 - nature.com
GABAergic inhibitory circuits play an essential role in coordinating various hippocampal
functions. Several decades of work dedicated to a thorough characterization of hippocampal …
functions. Several decades of work dedicated to a thorough characterization of hippocampal …
Synaptic memory and CaMKII
RA Nicoll, H Schulman - Physiological reviews, 2023 - journals.physiology.org
Ca2+/calmodulin-dependent protein kinase II (CaMKII) and long-term potentiation (LTP)
were discovered within a decade of each other and have been inextricably intertwined ever …
were discovered within a decade of each other and have been inextricably intertwined ever …