Applications of cucurbiturils in medicinal chemistry and chemical biology

D Das, KI Assaf, WM Nau - Frontiers in chemistry, 2019 - frontiersin.org
The supramolecular chemistry of cucurbit [n] urils (CB n) has been rapidly develo** to
encompass diverse medicinal applications, including drug formulation and delivery …

Cucurbit [10] uril-based chemistry

X Yang, F Liu, Z Zhao, F Liang, H Zhang, S Liu - Chinese Chemical Letters, 2018 - Elsevier
Abstract Cucurbit [n] urils (CB [n] s, n= 5–8, 10, 13–15) have been proven to be an
interesting macrocyclic family with their distinctive molecular recognition properties and …

Encapsulation of chemotherapeutic drug melphalan in cucurbit [7] uril: effects on its alkylating activity, hydrolysis, and cytotoxicity

G Villarroel-Lecourt, J Carrasco-Carvajal… - ACS …, 2018 - ACS Publications
The formation of inclusion complexes between drugs and macrocycles has proven to be an
effective strategy to increase solubilization and stabilization of the drug, while in several …

Cucurbiturils as reaction containers for photocycloaddition of olefins

M Pattabiraman, J Sivaguru… - Israel Journal of …, 2018 - Wiley Online Library
Abstract The [2+ 2] photocycloaddition (PCA [2+ 2]) of alkenes is one of the most
synthetically useful photoreactions. It is a convenient one‐step reaction that is useful for …

Supramolecular co-encapsulation of a photosensitizer and chemotherapeutic drug in cucurbit [8] uril for potential chemophototherapy

F Solis-Egaña, N Lavín-Urqueta, D Guerra Díaz… - Photochemical & …, 2022 - Springer
Supramolecular strategies as well as combinatorial approaches have been proposed to
improve cancer therapeutics. In this work, we investigated the encapsulation of the …

Europium doped calcium deficient hydroxyapatite as theranostic nanoplatforms: Effect of structure and aspect ratio

SP Victor, MG Gayathri Devi, W Paul… - ACS Biomaterials …, 2017 - ACS Publications
We present the development of theranostic nanoplatforms (NPs) based on a europium
(Eu3+) doped calcium deficient hydroxyapatite (CDHA) core functionalized with cyclodextrin …

[HTML][HTML] Photoinstability in active pharmaceutical ingredients: Crystal engineering as a mitigating measure

S SeethaLekshmi, TS Thakur, S Varughese - Journal of Photochemistry and …, 2021 - Elsevier
Cocrystallization has evolved as an attractive prospect to broaden the chemical landscape
of a drug entity, expand its therapeutic scope, and address physicochemical deficiencies of …

The extravascular penetration of tirapazamine into tumours: a predictive model of the transport and efficacy of hypoxia specific cytotoxic analogues and the potential …

CW Fong - … Journal of Computational Biology and Drug …, 2017 - inderscienceonline.com
A multiparameter model of the diffusion, antiproliferative assays IC50 and aerobic and
hypoxic clonogenic assays for a wide range of neutral and radical anion forms of …

Molecular recognition properties of acyclic cucurbiturils toward amino acids, peptides, and a protein

SA Zebaze Ndendjio, L Isaacs - Supramolecular Chemistry, 2019 - Taylor & Francis
The binding of 1 and 2 toward 19 amino acid amides by 1H NMR and ITC is reported. Hosts
1 and 2 bind to aromatic or hydrophobic residues by cavity inclusion leaving the cationic …

Host-appended reusable polymeric films for the quantitative separation of pyridine from azeotropic pyridine/toluene/benzene mixture

R Biswas, Y Lee, H Lee - European Polymer Journal, 2025 - Elsevier
Toluene and benzene are widely used raw materials in both industry and laboratory
research, where high purity is essential. However, their purification poses considerable …