Neuroimmune crosstalk in the cornea: The role of immune cells in corneal nerve maintenance during homeostasis and inflammation

M Wu, LJ Hill, LE Downie, HR Chinnery - Progress in Retinal and Eye …, 2022 - Elsevier
In the cornea, resident immune cells are in close proximity to sensory nerves, consistent with
their important roles in the maintenance of nerves in both homeostasis and inflammation …

Redefining our vision: an updated guide to the ocular immune system

M Wu, EL Fletcher, HR Chinnery, LE Downie… - Nature Reviews …, 2024 - nature.com
Balanced immune responses in the eyes are crucial to preserve vision. The ocular immune
system has long been considered distinct, owing to the so-called 'immune privilege'of its …

Redefining the human corneal immune compartment using dynamic intravital imaging

LE Downie, X Zhang, M Wu, S Karunaratne… - Proceedings of the …, 2023 - pnas.org
The healthy human cornea is a uniquely transparent sensory tissue where immune
responses are tightly controlled to preserve vision. The cornea contains immune cells that …

[HTML][HTML] Corneal tissue-resident memory T cells form a unique immune compartment at the ocular surface

JK Loi, YO Alexandre, K Senthil, D Schienstock… - Cell reports, 2022 - cell.com
The eye is considered immune privileged such that immune responses are dampened to
protect vision. As the most anterior compartment of the eye, the cornea is exposed to …

Potential ocular biomarkers for early detection of Alzheimer's disease and their roles in artificial intelligence studies

P Chaitanuwong, P Singhanetr, M Chainakul… - Neurology and …, 2023 - Springer
Alzheimer's disease (AD) is the leading cause of dementia worldwide. Early detection is
believed to be essential to disease management because it enables physicians to initiate …

Ophthalmic biomarkers for Alzheimer's disease: A review

A Majeed, B Marwick, H Yu, H Fadavi… - Frontiers in aging …, 2021 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
neuronal loss, extracellular amyloid-β (Aβ) plaques, and intracellular neurofibrillary tau …

Corneal immune cell morphometry as an indicator of local and systemic pathology: a review

HR Chinnery, XY Zhang, CY Wu… - Clinical & experimental …, 2021 - Wiley Online Library
The corneal epithelium contains a population of resident immune cells commonly referred to
as dendritic cells (DCs), or Langerhans cells. A unique advantage of the transparent cornea …

Intravital imaging of the human cornea reveals the differential effects of season on innate and adaptive immune cell morphodynamics

M Wu, X Zhang, S Karunaratne, J Lee, ER Lampugnani… - Ophthalmology, 2024 - Elsevier
Purpose Defining how the in vivo immune status of peripheral tissues is shaped by the
external environment has remained a technical challenge. We recently developed …

Oculomics: a crusade against the four horsemen of chronic disease

EJ Patterson, AD Bounds, SK Wagner… - Ophthalmology and …, 2024 - Springer
Chronic, non-communicable diseases present a major barrier to living a long and healthy
life. In many cases, early diagnosis can facilitate prevention, monitoring, and treatment …

Corneal nerve loss predicts dementia in patients with mild cognitive impairment

G Ponirakis, H Al Hamad, DAM Omar… - Annals of Clinical …, 2023 - Wiley Online Library
Objectives This study compared the utility of corneal nerve measures with brain volumetry
for predicting progression to dementia in individuals with mild cognitive impairment (MCI) …