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The neurobiology of social play and its rewarding value in rats
In the young of many mammalian species, including humans, a vigorous and highly
rewarding social activity is abundantly expressed, known as social play behaviour. Social …
rewarding social activity is abundantly expressed, known as social play behaviour. Social …
Phytocannabinoids and schizophrenia: Focus on adolescence as a critical window of enhanced vulnerability and opportunity for treatment
The recent shift in socio-political debates and growing liberalization of Cannabis use across
the globe has raised concern regarding its impact on vulnerable populations such as …
the globe has raised concern regarding its impact on vulnerable populations such as …
A randomised controlled trial of vaporised Δ9-tetrahydrocannabinol and cannabidiol alone and in combination in frequent and infrequent cannabis users: acute …
Access to cannabis and cannabinoid products is increasing worldwide for recreational and
medicinal use. Two primary compounds within cannabis plant matter, Δ 9 …
medicinal use. Two primary compounds within cannabis plant matter, Δ 9 …
Adolescent THC exposure causes enduring prefrontal cortical disruption of GABAergic inhibition and dysregulation of sub-cortical dopamine function
J Renard, HJ Szkudlarek, CP Kramar, CEL Jobson… - Scientific reports, 2017 - nature.com
Chronic adolescent marijuana use has been linked to the later development of psychiatric
diseases such as schizophrenia. GABAergic hypofunction in the prefrontal cortex (PFC) is a …
diseases such as schizophrenia. GABAergic hypofunction in the prefrontal cortex (PFC) is a …
Dopaminergic neurotransmission in the nucleus accumbens modulates social play behavior in rats
A Manduca, M Servadio, R Damsteegt… - …, 2016 - nature.com
Social play behavior is a highly rewarding form of social interaction displayed by young
mammals. Social play is important for neurobehavioral development and it has been found …
mammals. Social play is important for neurobehavioral development and it has been found …
Cannabidiol counteracts the psychotropic side-effects of δ-9-tetrahydrocannabinol in the ventral hippocampus through bidirectional control of erk1–2 phosphorylation
Evidence suggests that the phytocannabinoids Δ-9-tetrahydrocannabinol (THC) and
cannabidiol (CBD) differentially regulate salience attribution and psychiatric risk. The ventral …
cannabidiol (CBD) differentially regulate salience attribution and psychiatric risk. The ventral …
Cannabidiol counteracts amphetamine-induced neuronal and behavioral sensitization of the mesolimbic dopamine pathway through a novel mTOR/p70S6 kinase …
Schizophrenia-related psychosis is associated with disturbances in mesolimbic dopamine
(DA) transmission, characterized by hyperdopaminergic activity in the mesolimbic pathway …
(DA) transmission, characterized by hyperdopaminergic activity in the mesolimbic pathway …
Adolescent cannabinoid exposure induces a persistent sub-cortical hyper-dopaminergic state and associated molecular adaptations in the prefrontal cortex
Considerable evidence suggests that adolescent exposure to delta-9-tetrahydrocanabinol
(THC), the psychoactive component in marijuana, increases the risk of develo** …
(THC), the psychoactive component in marijuana, increases the risk of develo** …
Cannabidiol modulates fear memory formation through interactions with serotonergic transmission in the mesolimbic system
C Norris, M Loureiro, C Kramar, J Zunder… - …, 2016 - nature.com
Emerging evidence suggests that the largest phytochemical component of cannabis,
cannabidiol (CBD), may possess pharmacotherapeutic properties in the treatment of …
cannabidiol (CBD), may possess pharmacotherapeutic properties in the treatment of …
Δ-9-Tetrahydrocannabinol and Cannabidiol produce dissociable effects on prefrontal cortical executive function and regulation of affective behaviors
The use of cannabis for therapeutic and recreational purposes is growing exponentially.
Nevertheless, substantial questions remain concerning the potential cognitive and affective …
Nevertheless, substantial questions remain concerning the potential cognitive and affective …