The RNA modification N6-methyladenosine as a novel regulator of the immune system
Protection from harmful pathogens depends on activation of the immune system, which
relies on tight regulation of gene expression. Recently, the RNA modification N 6 …
relies on tight regulation of gene expression. Recently, the RNA modification N 6 …
BCL-2 protein family: attractive targets for cancer therapy
Acquired resistance to cell death is a hallmark of cancer. The BCL-2 protein family members
play important roles in controlling apoptotic cell death. Abnormal over-expression of pro …
play important roles in controlling apoptotic cell death. Abnormal over-expression of pro …
The miR-142 miRNAs: Sha** the naïve immune system
WJ Olson, E Derudder - Immunology Letters, 2023 - Elsevier
Immunity in a naïve organism is tightly controlled. Adequate proportions of the many immune
cell subsets must be produced to mount efficient responses to eventual challenges. In …
cell subsets must be produced to mount efficient responses to eventual challenges. In …
A MIR17HG-derived long noncoding RNA provides an essential chromatin scaffold for protein interaction and myeloma growth
Long noncoding RNAs (lncRNAs) can drive tumorigenesis and are susceptible to
therapeutic intervention. Here, we used a large-scale CRISPR interference viability screen …
therapeutic intervention. Here, we used a large-scale CRISPR interference viability screen …
MicroRNA miR-181—A Rheostat for TCR signaling in thymic selection and peripheral T-cell function
Z Grewers, A Krueger - International journal of molecular sciences, 2020 - mdpi.com
The selection of T cells during intra-thymic d evelopment is crucial to obtain a functional and
simultaneously not self-reactive peripheral T cell repertoire. However, selection is a complex …
simultaneously not self-reactive peripheral T cell repertoire. However, selection is a complex …
A high-resolution map of functional miR-181 response elements in the thymus reveals the role of coding sequence targeting and an alternative seed match
NA Verheyden, M Klostermann… - Nucleic Acids …, 2024 - academic.oup.com
MicroRNAs (miRNAs) are critical post-transcriptional regulators in many biological
processes. They act by guiding RNA-induced silencing complexes to miRNA response …
processes. They act by guiding RNA-induced silencing complexes to miRNA response …
Parallel genetics of regulatory sequences using scalable genome editing in vivo
How regulatory sequences control gene expression is fundamental for explaining
phenotypes in health and disease. Regulatory elements must ultimately be understood …
phenotypes in health and disease. Regulatory elements must ultimately be understood …
The Role of MicroRNAs in Development and Function of Regulatory T Cells–Lessons for a Better Understanding of MicroRNA Biology
H Kunze-Schumacher, A Krueger - Frontiers in immunology, 2020 - frontiersin.org
MicroRNAs (miRNAs) have emerged as critical posttranscriptional regulators of the immune
system, including function and development of regulatory T (Treg) cells. Although this critical …
system, including function and development of regulatory T (Treg) cells. Although this critical …
MicroRNA‑25‑3p regulates human nucleus pulposus cell proliferation and apoptosis in intervertebral disc degeneration by targeting Bim
Z Zhao, J Zheng, Y Ye, K Zhao… - Molecular …, 2020 - spandidos-publications.com
Intervertebral disc degeneration (IDD) is a degenerative disease of the spine originating
from the intervertebral disc. MicroRNAs (miRNAs or miRs) are a group of endogenous small …
from the intervertebral disc. MicroRNAs (miRNAs or miRs) are a group of endogenous small …
MicroRNA regulation of B cell receptor signaling
B lymphocytes play a central role in host immune defense. B cell receptor (BCR) signaling
regulates survival, proliferation, and differentiation of B lymphocytes. Signaling through the …
regulates survival, proliferation, and differentiation of B lymphocytes. Signaling through the …