Precisely how the anatomical structure of the brain gives rise to a repertoire of complex
functions remains incompletely understood. A promising manifestation of this map** from …

Mobility is the most studied and most relevant physical ability affecting quality of life with
strong prognostic value for disability and survival. Natural selection has built the “engine” of …

Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide …

A critical issue in many neuroimaging studies is the comparison between brain maps.
Nonetheless, it remains unclear how one should test hypotheses focused on the overlap or …

The normal aging human brain experiences global decreases in metabolism, but whether
this affects the topography of brain metabolism is unknown. Here we describe PET-based …

Brain imaging can be used to study how individuals' brains are aging, compared against
population norms. This can inform on aspects of brain health; for example, smoking and …

Although approximately 90% of the US population will experience a traumatic event within
their lifetime, only a fraction of those traumatized individuals will develop posttraumatic …

There is a growing realization that early life influences have lasting impact on brain function
and structure. Recent research has demonstrated that genetic relationships in adults can be …

Importance It is controversial whether epilepsy is a static or progressive disease. Evidence
of progressive gray matter loss in epilepsy would support early diagnosis, rapid treatment …

Maternal immune activation (MIA) during pregnancy has been linked to an increased risk of
develo** psychiatric pathologies in later life. This link may be bridged by a defective …