We use dynamic micro-computed tomography (micro-CT) with a high temporal resolution to
visualize water penetration through the porous network of immediate-release …

Background The tablet is the most common drug formulation in the pharmaceutical industry.
With the invention of new pharmaceutical tablet compression technologies, more advanced …

During early drug product development, methods for characterization of mechanical
attributes are developed for flat, round tablets. However, there is a lack of understanding on …

A numerical study of the tableting process using a finite element method (FEM) is important
to quantitatively understand the structural change inside the tablet and the mechanism of …

We present generalized loading-unloading contact laws for elasto-plastic spheres with
bonding strength. The proposed mechanistic contact laws are continuous at the onset of …

We adopt a Quality by Design (QbD) paradigm to better control the mechanical properties of
tablets. To this end, the effect of particle size distribution, lubricant concentration, and mixing …

We develop a particle-to-particle solvent diffusion model for compacted granular systems
that addresses a long-standing gap in particle-to-particle transport models. The proposed …

The interfacial bonding strength (IBS) of four different layer combinations between
microcrystalline cellulose (MCC) and lactose (Lac), ie, MCC/MCC, Lac/Lac, MCC/Lac and …

This work aimed to explore the combination of hydrophilic and hydrophobic cyclodextrins to
prepare bilayer tablets that can perform as quick/slow biphasic release systems of a poorly …

To take full advantage of the drug delivery benefits offered by bilayer tablets, the common
issue of weak interfacial bonding strength (IBS) with manufacturing must be overcome. This …