[HTML][HTML] The role of albumin in critical illness

JP Nicholson, MR Wolmarans, GR Park - British journal of anaesthesia, 2000 - Elsevier
The last 25 yr have seen major advances in our understanding of albumin. We now know
the amino acid sequences of bovine and human albumin, the complete gene sequence of …

Idiosyncratic adverse drug reactions: current concepts

J Uetrecht, DJ Naisbitt - Pharmacological reviews, 2013 - Elsevier
Idiosyncratic drug reactions are a significant cause of morbidity and mortality for patients;
they also markedly increase the uncertainty of drug development. The major targets are skin …

[SÁCH][B] All about albumin: biochemistry, genetics, and medical applications

T Peters Jr - 1995 - books.google.com
The first of its kind, All About Albumin summarizes the chemistry, genetics, metabolism,
clinical implications, and commercial aspects of albumin. It provides the most up-to-date …

Molecular and practical aspects of the enzymatic properties of human serum albumin and of albumin–ligand complexes

U Kragh-Hansen - Biochimica et Biophysica Acta (BBA)-General Subjects, 2013 - Elsevier
Background Human serum albumin and some of its ligand complexes possess enzymatic
properties which are useful both in vivo and in vitro. Scope of review This review …

Immunological principles of adverse drug reactions: the initiation and propagation of immune responses elicited by drug treatment

DJ Naisbitt, SF Gordon, M Pirmohamed, BK Park - Drug safety, 2000 - Springer
Adverse drug reactions account for between 2 to 5% of all hospital admissions and can
prevent the administration of an otherwise effective therapeutic agent. Hypersensitivity or …

Hypersensitivity reactions to β-lactams: relevance of hapten-protein conjugates.

A Ariza, C Mayorga, TD Fernandez… - … allergology & clinical …, 2015 - europepmc.org
β-Lactams (BL) are the drugs most frequently involved in allergic reactions. They are
classified according to their chemical structure as penicillins, cephalosporins, monobactams …

Characterisation of flucloxacillin and 5‐hydroxymethyl flucloxacillin haptenated HSA in vitro and in vivo

RE Jenkins, X Meng, VL Elliott… - PROTEOMICS …, 2009 - Wiley Online Library
Flucloxacillin is a synthetic penicillin used in the treatment of Staphylococcal infections.
Adverse reactions to the drug are believed to arise through covalent modification of proteins …

Idiosyncratic drug reactions: a mechanistic evaluation of risk factors

BK Park, M Pirmohamed… - British journal of clinical …, 1992 - pmc.ncbi.nlm.nih.gov
Adverse drug reactions area major complication of modern drug therapy; they are a
considerable cause of patient morbidity and account for a significant number of patient …

Metabolic activation in drug allergies

BK Park, DJ Naisbitt, SF Gordon, NR Kitteringham… - Toxicology, 2001 - Elsevier
Drug allergies are a major problem in the clinic and during drug development. At the present
time, it is not possible to predict the potential of a new chemical entity to produce an allergic …

Advances in molecular toxicology–towards understanding idiosyncratic drug toxicity

BK Park, NR Kitteringham, H Powell, M Pirmohamed - Toxicology, 2000 - Elsevier
Idiosyncratic drug toxicity is a major complication of drug therapy and drug development.
Such adverse drug reactions (ADRs) include anaphylaxis, blood dyscrasias, hepatotoxicity …