Cultivating meat from stem cells rather than by raising animals is a promising solution to
concerns about the negative externalities of meat production. For cultivated meat to fully …

Background Cultured meat has emerged as a breakthrough technology for the global food
industry, which was considered as a potential solution to mitigate serious environmental …

Apoptosis is a form of programmed and controlled cell death that accounts for the majority of
cellular death in bioprocesses. Cell death affects culture longevity and product quality; it is …

Cell-based meat, or cultured meat is at the early commercialization stage, but thorough
considerations of the scaling-up challenges are scarce and the physiological data of animal …

In this work, two external filtration devices for cell retention, the commercial alternating
tangential flow (ATF) system and a tangential flow filtration (TFF) setup driven by a …

Transfer of mammalian cell culture processes across stirred and aerated bioreactor scales is
a delicate task, frequently leading to different conditions across scales. To provide a more …

The hydromechanical stress is a relevant parameter for mammalian cell cultivations,
especially regarding scale-up processes. It describes the mechanical forces exerted on cells …

In order to meet the rising demand for biologics and become competitive on the develo**
biosimilar market, there is a need for process intensification of biomanufacturing processes …

Maintaining desired pH is a necessity for optimal cell growth and protein production. It is
typically achieved through a two-sided pH control loop on the bioreactor controller. Here we …

Reliable scale-up of biopharmaceutical production processes is key in Quality by Design. In
this study, a model-based workflow is described to evaluate the bioprocess dynamics during …