Major achievements in bone research have always relied on animal models and in vitro
systems derived from patient and animal material. However, the use of animals in research …

This review is a comprehensive analysis of the cell biology and biomechanics of Convergent
Extension in Xenopus.

Gastruloids have emerged as highly useful in vitro models of mammalian gastrulation. One
of the most striking features of 3D gastruloids is their elongation, which mimics the extension …

Morphogenesis is governed by the interplay of molecular signals and mechanical forces
across multiple length scales. The last decade has seen tremendous advances in our …

Multicellular aggregates are known to exhibit liquid-like properties. The fusion process of
two cell aggregates is commonly studied as the coalescence of two viscous drops. However …

Convergent extension (CE) is an evolutionarily conserved collective cell movement that
elongates several organ systems during development. Studies have revealed two distinct …

Simulating morphogenesis of both mesenchyme and epithelium has typically required
complex and computationally expensive models. To meet this challenge, we developed ya …

Despite continual renewal and damages, a multicellular organism is able to maintain its
complex morphology. How is this stability compatible with the complexity and diversity of …

The shape of the epithelial monolayer can be depicted as a curved tissue in three-
dimensional (3D) space, where individual cells are tightly adhered to one another. The 3D …

Branching morphogenesis is a characteristic feature of many essential organs, such as the
lung and kidney, and most glands, and is the net result of two tissue behaviors: branch point …