Horizontal gene transfer (HGT) is arguably the most conspicuous feature of bacterial
evolution. Evidence for HGT is found in most bacterial genomes. Although HGT can …

Pertussis, which is caused by Bordetella pertussis, has plagued humans for at least 800
years, is highly infectious and can be fatal in the unvaccinated, especially very young …

A perfect bacterial genome assembly is one where the assembled sequence is an exact
match for the organism's genome—each replicon sequence is complete and contains no …

Mobile genetic elements are key to the evolution of bacteria and traits that affect host and
ecosystem health. Here, we use a framework of a hierarchical and modular system that …

Microbial pathogenesis studies are typically performed with reference strains, thereby
overlooking within-species heterogeneity in microbial virulence. Here we integrated human …

Transposable elements (TE), small mobile genetic elements unable to exist independently
of the host genome, were initially believed to be exclusively deleterious genomic parasites …

Insertion sequences (ISs), arguably the smallest and most numerous autonomous
transposable elements (TEs), are important players in sha** their host genomes. This …

Invasive strains of non-typhoidal salmonellae have emerged as a prominent cause of
bloodstream infection in African adults and children, with an associated case fatality of 20 …

Background Several genome-scale metabolic reconstruction software platforms have been
developed and are being continuously updated. These tools have been widely applied to …

Aminoglycosides have been an essential component of the armamentarium in the treatment
of life-threatening infections. Unfortunately, their efficacy has been reduced by the surge and …