Non‐immunosuppressive cyclophilin inhibitors
C Schiene‐Fischer, G Fischer… - Angewandte Chemie …, 2022 - Wiley Online Library
Cyclophilins, enzymes with peptidyl‐prolyl cis/trans isomerase activity, are relevant to a
large variety of biological processes. The most abundant member of this enzyme family …
large variety of biological processes. The most abundant member of this enzyme family …
Molecular characterization of circulating tumor cells in patients with ovarian cancer improves their prognostic significance—a study of the OVCAD consortium
E Obermayr, DC Castillo-Tong, D Pils, P Speiser… - Gynecologic …, 2013 - Elsevier
OBJECTIVE: The study aims at identifying novel markers for circulating tumor cells (CTCs) in
patients with epithelial ovarian cancer (EOC), and at evaluating their impact on outcome …
patients with epithelial ovarian cancer (EOC), and at evaluating their impact on outcome …
The antifungal drug itraconazole inhibits vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, trafficking, and signaling in endothelial cells
Itraconazole is a safe and widely used antifungal drug that was recently found to possess
potent antiangiogenic activity. Currently, there are four active clinical trials evaluating …
potent antiangiogenic activity. Currently, there are four active clinical trials evaluating …
Inflammation‐controlled anti‐inflammatory hydrogels
T Helmecke, D Hahn, N Matzke, L Ferdinand… - Advanced …, 2023 - Wiley Online Library
While autoregulative adaptation is a common feature of living tissues, only a few feedback‐
controlled adaptive biomaterials are available so far. This paper herein reports a new …
controlled adaptive biomaterials are available so far. This paper herein reports a new …
[HTML][HTML] A novel implant surface modification mode of Fe3O4-containing TiO2 nanorods with sinusoidal electromagnetic field for osteoblastogenesis and angiogenesis
R Ren, J Guo, H Song, Y Wei, C Luo, Y Zhang… - Materials Today Bio, 2023 - Elsevier
Implants made of Ti and its alloys are widely utilized in orthopaedic surgeries. However,
insufficient osseointegration of the implants often causes complications such as aseptic …
insufficient osseointegration of the implants often causes complications such as aseptic …
[HTML][HTML] Endoplasmic reticulum vacuolation and unfolded protein response leading to paraptosis like cell death in cyclosporine A treated cancer cervix cells is …
BM Ram, G Ramakrishna - Biochimica et Biophysica Acta (BBA)-Molecular …, 2014 - Elsevier
Cyclosporine A (CsA), a widely used immunosuppressant shows cytotoxic effects by either
inducing apoptosis or redirecting the cell towards non-apoptotic cell death. However, there …
inducing apoptosis or redirecting the cell towards non-apoptotic cell death. However, there …
[HTML][HTML] Current update on theranostic roles of cyclophilin A in kidney diseases
S Hadpech, V Thongboonkerd - Theranostics, 2022 - ncbi.nlm.nih.gov
Cyclophilin A (CyPA) or peptidylprolyl isomerase A (PPIA), an immunophilin with peptidyl-
prolyl cis/trans isomerase (PPIase) activity, is an abundant cellular protein widely expressed …
prolyl cis/trans isomerase (PPIase) activity, is an abundant cellular protein widely expressed …
Cyclosporine A induces cardiac developmental toxicity in zebrafish by up-regulation of wnt signaling and oxidative stress
M Wan, L Huang, J Liu, F Liu, G Chen, H Ni… - Frontiers in …, 2021 - frontiersin.org
Due to the widely application of Cyclosporine A (CsA) as an immunosuppressant in clinic, it
is necessary to study its potential toxicity. Therefore, we used zebrafish as a model animal to …
is necessary to study its potential toxicity. Therefore, we used zebrafish as a model animal to …
Itraconazole side chain analogues: structure–activity relationship studies for inhibition of endothelial cell proliferation, vascular endothelial growth factor receptor 2 …
Itraconazole is an antifungal drug that was recently found to possess potent antiangiogenic
activity and anti-hedgehog (Hh) pathway activity. To search for analogues of itraconazole …
activity and anti-hedgehog (Hh) pathway activity. To search for analogues of itraconazole …
[HTML][HTML] Mitochondrial permeability regulates cardiac endothelial cell necroptosis and cardiac allograft rejection
I Gan, J Jiang, D Lian, X Huang, B Fuhrmann… - American Journal of …, 2019 - Elsevier
Transplantation is invariably associated with programmed cell death including apoptosis
and necrosis, resulting in delayed graft function and organ rejection. We have demonstrated …
and necrosis, resulting in delayed graft function and organ rejection. We have demonstrated …